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Disco Germinativo BilaminarDr. Abelardo Arias Velsquez
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Clulas germinales
Fecundacin e implantacin
PRIMERA SEMANA DE DESARROLLOEMBRIONARIO
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Formacindelblastocisto
SEGMENTACIN
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ImplantacinEmbrin se implanta en tero
Embrin
endometrio tero
mecanismo
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Anomalas de la Implantacin
Embarazo tubrico
Lugares ms frecuentes
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SEGUNDA SEMANA DE DESARROLLOEMBRIONARIO
Masa celular interna
Epiblasto
Hipoblasto
Dia 8
(embrioblasto)
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membrana amnitica
El epiblastoamnioblastos
saco amnitico
El hipoblastomigracin lateralde clulaspara tapizar la
superficie delblastoceleFormacin demembrana de Heuser
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Trofoblasto
Citotrofoblasto
Sincitiotrofoblasto
Dia 10
Capa de clulas mononucleadas con actividad mittica
Masa multinucleada de expansin rpida
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Disco Germinativo TrilaminarDr. Abelardo Arias Velsquez
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Disco germinativo hacia el final de la segunda semana. El hipoblasto y el
epiblasto se encuentran en contacto entre s y la linea primitiva forma un surco
poco profundo hacia la regin caudal
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GENTICA DEL DESARROLLOHUMANODr. Abelardo Arias Velasquez
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PreguntasBiologia del desarrollo
Como a partir de una clula se llega aun organismo entero?
Cmo sabe un embrin que genes tieneque encender o apagar?
Por qu tenemos la cabeza en lacabeza y la cola en la cola?
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Estructura bsica de una gen
aaa ttt ccc ccg gga ttg ggattt aaa ggg ggg cct aac cct
aaa ttt ccc ccg gga ttg ggattt aaa ggg ggg cct aac cctttt aaa ggg ggg cct aac cctttt aaa ggg ggg cct aac cct
1 2 3 4 5 6
Exn Intrn
RNA
Protena
splicing
Regulacion
P l l
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Procesos moleculares
Premio Nobel de Medicina y Fisiologa 2002. Sydney Brenner, Robert Horvitz y
John Sulston
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Ciclo celular
Proto oncogenSupresor tumoral
Apoptosis
Mitosis
El huevo o la gallina (que fue
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El huevo o la gallina (que fueprimero??)
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Diferenciacincelular
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Incrementofactor
crecimiento
Incrementoreceptor
factorcrecimiento
Aumento deseales de
transduccin
Incremento en laactividad detranscripcin
Mecanismos de diferenciacin celular
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Secuencia del control gentico
Genes de efecto materno
- Bicoid- Oskar- Swallow- Caudal- Torso- Trunk
Genes de segmentacin
- Empty- Hunchback- Krupel- Knirps- Orthodenticle- Tailles
Pair rule
Polaridad segmentaria
- Hairy- Runt- Fushi tarazu- Hedhehog- Patchet- Smoothened
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Comunicacin celular y genes
Molculasreceptoras
Seales detransduccin
Factores deTranscripcin
citoplasma
ncleo
Molculas desenalizacin
GENES DELDESARROLLO
F t d t i i
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Factores de transcripcin
Clases de factores: Protena Helice-lazo-helice
Protenas en dedo de Zinc Protenas homeodominio
Genes homeoticos Antennapedia
Bithorax
Suelen ser fundamentales en los patrones de expresin gnica
1 2 3 4 5 6Regulacion
Factores de transcripcin:
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Genes Hox Genes Pax Genes Sox
Factores de transcripcin:homeobox
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Factores de transcripcin: Hox C-6
Homeobox & Hox Genes
F t d t i i HOX
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http://www.people.virginia.edu/~rjh9u/homeo.html
(Drosophila and Mus)Factores de transcripcin: HOX
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Protenas homeodominio secuencia
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Protenas homeodominio secuenciahomeobox
Genes Hox: el raton y el ser humano poseen 39 genes homeobox, distribuidos en cuatro cromosomas formandocuatro grupos.
Hoxa (Hox-1)
Hoxb (Hox-2)
Hoxc (Hox-3)
Hoxd (Hox-4)
A1 A2 A3 A4 A5 A6 A7 A9 A10 A11 A13
B1 B2 B3 B4 B5 B6 B7 B8 B9 B13
C4 C5 C6 C8 C9 C10 C11 C12 C13
D1 D3 D4 D8 D9 D10 D11 D12 B13
Direccin de la transcripcion
Direccin de la expresin
Malformaciones del miembro
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Malformaciones del miembrosuperior
Amelia Hemimelia
AqueiliaAdactilia
Ectrodactilia
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FOCOMELIA
Cortesia: Dr. Miguel Chavez
Factores de transcripcin: PAX
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Factores de transcripcin: PAXMuchos aspectos del desarrollo, rganos de los sentidos, SN, etc.
Los rganos sensibles a la luz tienen un ancestro comn
opsina
Fotoreceptor
Pigmentos
Ciulas
Pigmentarias
opsina
fotoreceptor
Ojo devertebrado
cornea
lente
Bastones y conos
Nervio
ptico
cornea
lentelente
Ojo deartrpodo
Dif i i l
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Diferenciacin sexual
Factores de transcripcin: SOX
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DIFERENCIACION UROGENITAL
Adrenal
Gnada
Rin
Agenesia Gonadal
y renal
Agenesia Gonadaly adrenal
Ovario
Testculo
SRY SOX9
DAX
Factores de transcripcin: SOXSe expresan durante alguna fase del desarrollo, diferenciacion sexual, etc
M l l li d
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Intervienen en lasinteracciones de los gruposcelulares La familia TGF- B(Factor de
crecimiento transformante Beta)
La familia FGF (Factor de crecimientofibroblstico) La familia Hedgehog
Molculas sealizadoras
Caractersticas Clnicas: Mutacin
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Caractersticas Clnicas: Mutacinde IGF
(Factor de crecimiento similar a insulina) Macrosomia Macroglosia
Onfalocele Hipoglicemia Visceromegalia Adrenocortical
citomegalia
NefroblastomaBeckwith Wiedeman
D ll d i b
M l l li d
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Desarrollo de miembrosMolculas sealizadoras
D ll d l i b i
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Desarrollo del miembro superior
PAX
Regulacin molecular en el
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gdesarrollo de miembros
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14
15
16
17
18
19
20
21
22
23
FGF10
13
14
15
16
17
18
19
20
21
22
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FGF8
Shh
13
14
15
16
17
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FGF8+
FGF4
Shh
Tubo neuralSomites
Mesodermo intermedioMesodermo Lateral
Induccin Respuesta Mantenimiento
activ
acin
A d ti id d d i
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Areas de actividad mesodrmica
rea decrecimiento
CEA FGF1,2,4
FGF10
Zona de
actividadpolarizante
CEA: Cresta ectodrmica apical
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Sindactilias
Sindrome de ApertMalformacin
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SHHSonic Hedhegog
Malformacion
S i H d h
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Sonic Hedgehog
CI
Microtubulo
Cos2
Fused
PKASlimb
Reprime expresin gentica
Patched
smoothened
GLI
Molculasreceptoras
Transduccin de la
seal
Expresin gnica
shh
si todas las clulas tiene el mismo material genetico como
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EPIGENTICA
ges que existen diferentes tejidos? mmmm?
Epigentica
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Epigentica
El proceso de regulacin gentica seproduce por la metilacin o acetilacin del
ADN e histonas respectivamente
3 4 5 6 7 8 9 10 11
Reguladora Regin de trascripcin
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Copyright 2005 American Physiological Society
Generacin de clulas pancreticas a partir de clulas troncales
Problema!!!!!!
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Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
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Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
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Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
Genes
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Genes
Genes
Genes
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Genes
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Genes
Genes
TIEMPO
Problema!!!!!!
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Cual es el
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blanco?
En resumen los genes del
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En resumen los genes del
desarrollo Dirigen el desarrollo embrionario por
medio de diferentes mecanismos: Factores de transcripcin
Reguladores transcripcionales
Molculas sealizadoras Factores de crecimiento Receptores
Vias de sealizacin
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Gracias
por suatencin
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