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Oscar Leonardo Mosquera Dussan.
Ingeniero Electrnico.
Universidad de la Sabana.
Facultad de Ingeniera.
Doctorado en Biociencias.
Componente gentico de Epilepsia en lbulo temporal
Introduccin
Estudios recientes reportan mutacin de la protena leucine-rich glioma-inactivated-1
(LGI1), como causa de epilepsia parcial en humanos [1-3], anormalidad en el gen LGI1asociado a la protena es responsable de epilepsia autonmica dominante de lbulo
temporal [4-6]. Tambin se presenta un rol del gen LGI1 en epilepsias autoinmunes [7].
En la actualidad, poco se sabe sobre el patrn de expresin temporal y espacial del gen
LGI1 durante la embriognesis normal, un reciente estudio con un ratn transgnico
implican que Lgi1 puede tener un papel en el establecimiento de la arquitectura normal
del cerebro y funciones neuronales durante el desarrollo cerebral lo que sugiere que
pueden estar implicados en la neurognesis y la plasticidad neuronal, que se define ms
especficamente en el animal adulto [8]. Otro estudio en animales muestra que el
truncamiento del gene LGI2 (homologo al gen LGI1 en humanos) muestra una remisin de
epilepsia focal en perros [9]; estudios sugieren que ambos genes presentan una gran
similitud en los mecanismos moleculares de la patognesis [10].
En el presente trabajo se realiza un estudio bioinformtico al gen LGI1, se estudian las
secuencias de ADN, ARNm, y la secuencia de aminocidos que forman la protena leucine-
rich glioma-inactivated-1.
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En ncbi se puede apreciar la informacin del gen LGI1 asociado a epilepsia de lbulo
temporal.
EL gen se encuentra ubicado en el cromosoma 10 y la presente secuencia no tiene
splicing alternativo.
La secuencia del gen en formato FASTA es la siguiente,
>gi|224589801:95517566-95557916 Homo sapiens chromosome 10, GRCh37.p5 Primary Assembly
GAAAGCAGAAAGCTGTTTATTTTCTGTGACATCACTTCACTTTGCCTTCGAAGGCTGGTCTGTGCTCAGT
GTTTTCGTGGTGATGCAAGTCGGCTCTCTCCTCCAGCAGTTGGATCCCTCCCATCTCACAGTACCTCACA
GGTCTCTTCCCCCGAGCAGTGCATTGCTGGAGCGAGGAGAAGCTCACGAATCAGCTGCAGGTCTCTGTTT
TGAAAAAGCAGAGATACAGAGGCAGAGGAAAAGGGTGGACTCCTATGTGACCTGTTCTTAGAGCAAGACA
ATCACCATCTGAATTCCAGAAGCCCTGTTCATGGTTGGGGATATTTTCTCGACTGCATGGAATCAGAAAGAAGCAAAAGGATGGGAAATGCCTGCATTCCCCTGAAAAGAATTGCTTATTTCCTATGTCTCTTATCTGCG
CTTTTGCTGACTGAGGGGAAGAAACCAGCGAAGCCAAAATGCCCTGCCGTGTGTACTTGTACCAAAGATA
ATGCTTTATGTGAGAATGCCAGATCCATTCCACGCACCGTTCCTCCTGATGTTATCTCATTGTAAGGCCC
GTAAGCATTTTGATATCTAATTTACGATTTAAAAATTCCAGCCGGTGGATTTGGGGCTTTGCATGTATTT
GTAGAAGGGCATGGAGAGAGAGATTCCTCTTGCATGCTTGGCCATTTGACAGTGCTAACATTTGCTGCAT
TTAGAATTTTTGATTTTTTTAGCTGCTACTGAACATGCTTAGATACCCCCAGCCCTGAACATTATCATGA
GAAACCTGTAGCCGATTCATTTCTCTTACTTCATCTGGGAAGGAATAGTATCGTACTTCATAAAATAGTG
TCAAAATAGTCACTGTTATGCTAAACCGGATTAACATAAGGTTTGTTCTGTGTGTGTGTGTCTCTTTGTG
TGTGTCTGTTTGTTTGTTTTCTCTTTTTTGTTTTCTTTCAGATCCTTTGTGAGATCTGGTTTTACTGAAA
TCTCAGAAGGGAGTTTTTTATTCACGCCATCGCTGCAGCTCTTGTGAGAAATATTTATATCATGACTATT
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TTTAATATGGCATATATTTGGATAAGCCTTCTAGTAAAATGATCTCAATATTAATTTTGTCAAATGTGAT
TCTATTTCTGAGAAAACAGAATATCCGTAAAGTGAGAGGTAGATGGGTTTGTTTGCGACTTCACACCAAC
AGTGCAGGTTGATTCTTACAATGGTAAATCTGTTAACCTGTCATGCTGTCTACTTTAATGGCTATTTATG
AAGTTGTTGGAATCTTGCAACAATGATCCCAATTCCATTCCACTATTTTACTTTCATTTTTAACTTGGGA
ACTTGGGTTCTTTTGCCCTGGAGTTTTTGAATTAGTCAATACAGAACCCAGCATAACATATGCGCTCAAG
ATGTTGTCTCCGGGGATCTGGGGCAGGCTGCTACTCTGTATGATTTACCATGTGGGGAAAAAAAACACCT
CAGCTCTTTCTAGGTAATTCCTTAAAATGTTAATTCTCAAGAGACTGTTTTTTAATCTCATCTAATTTAT
AACTAGTTCCATTACAAGGAGGGAAAGAAAATATTAATATAGGATAGTGCAAAGGATTACTCTCTGCTAT
ATGTTTTGAGTTGGCCACAAGGGAACCACATACTCAGTCTATGCCTGAAAATATTCAAAAAAATAATATT
TGACTAAGAAATCAGATCTGTTCACAGGCATAATGGAACACATAAAATTTGTTCTGATGTGTAATGTTTG
GCAATTGGAGTCCTAGTCCTTACAGCGGTATCACATGGGGGTCAAGAGGTCTCCCAGGACTCAGGTATCA
GGTCGCAGACTTGGTTTGTAGCTGGACGGATATGGGCAGAATTAGACAATTGTGGATCAGCTGAGTCTTG
GCTATCTTAACTGCATGATTCAGGACCCAGGCCTTTCACTTGTTTGTTTTTTATTTTTTTATTTTCTTGC
CTTACTTGGCCATTTTGGCTGTTTGAAGTTACATACACAGAGGCAAACAGCATGGAGTGGACGTTGGAGA
GACAAGTGTTTAAACCTCACCCTGCCACTCATAGAACCTAAACATGTAGTCTTGTGCAGATTAGTATATC
TCACTAAGCCTCAGTCTTCTTATCTTTAAAATGGAAGTGAGAACACATACTTCCAAGGTTTAAGTAGATA
AAACACTTGGCATAGGGTGTGCCAAATGCTTACACATTTATAAATGGTAGGGTTTAAAAATTTTATATCA
AGCTAAAAAGCTAAAAGTCACTCATCTATTGTTTTGTGTATATGAAATTCCTAAACTGGTTTGACTGTTT
CATTGGATTCACAAACTTGATCAGTTGTTTTGACATTATGTAATGATGTTGGCTAATGCCCTTCTACTGG
CTGATGTCTTCAAATGATTAGCAATTGACTAGATATTCCTAAGGGGTTTATCTGTTTGATTGATGGCTAG
TGGTGTGACTGGGGGAAGTGTTAGTTAGCACATCAAACAAATCCAAAAAAGATAGATTCTTTCCCACAGA
AAGGGGCAGAGTCTCTAATGCTGGGATCCTTCCATAGGATAAGAATTTGCTGTCTCTGAGAAAGTGATAA
ATTGTGTTTCTGGTCCTCACTTGTTAAATGAATAAATAGCTCTTTTAAAAAGCATCCTTTTGATATGCTA
AGGCACCTCCCTTCCCCTAGGAAGTTACATAGATCTAGTTACATAGATCAGTCCTTAAAATTCCAGGAGTAGTGTCAGTAGACACTAGATGGACATTAGCTGTGGCACAGAAAGCCTGGAGTGATTAACCTAATCAATTA
CCACATCTCCACTTTGTTTTTGTTGGGTGGACCCAGTCACGGCAAGCACAGATGCTGGACAATGTTATAG
AAATAGTTACCGGCTGCTGCAGGGTAATGTGATTTCACGTATTTAGAATCACAGAGGGAAGCCAAGGGAC
TGGTTTTTAAATAGCCCAACCGAGTGTGTGCCATGCCCGTGCCCCATGCTCCGAGTTCCTATGGAACATT
CCAGCCTTTATTTCTAAAAGCAGTTCAGGTTTCAGAAATAACAAAAGGCGAGTAATTCTCTCCCAGTGTG
TTCTCGGTTAACTCAGATTGGCTAACCTCAACATGGTAGACTTGTGCCAGAGCTGAACTTATGCAAAATT
GTCAGGGGCCAAAGTTTGTCCCTAATCTCCAGGACCCTGTGCCTGAAGACTCTGCTCTCCATCCTTCTTG
CCCAATATTCTCTGCTTCCGCCTATCCTCAGGAAAAGGTCTAATAAACTCATGTGCGGTGTGTAGGAAAT
ATATGAGAAGGCTCTGAATATGAACTATGAAACGATCATAACAATTGTGGGAATGCATGGATCCCACAGA
GAAAGATCTCTTCTGTGAGACAGGGCTGTCCAGTGCCCTGAAAACCCCATATGGGCTGCCAATCCCCCTT
TGGAACATGAAGACCAATGGCATTGGACCACCAGATTAGGCCTAGATCACACAAGCCATTGAGGTTTGCA
ATGAATTCCAACAGCATTTGTGATTGTGAATTGCCACACTCACCCATCATACACTGTGAAGAGATAAATT
TCAGAATCAATTCGGCTTGATTGACGTAGGAAGACAGTTCGTTGGTTTCTTGCTTTATTGTTGGGAAGGG
TTAAAGCAAATGTCCTATTTCCATCATCCACCCTAAAAATCTGATAATGTCAGTATGCCCCCAGATGCTT
TTTCAGAGCTTCTGAAAAAGCTATGATGAGAAGTACTTGTTGAAATGTCAGTCTGGGGTACTGAGGAAAATAGACATGGTATCTGAAGTTACATGCAGTGTTTGGGAAAAGATCCTGGTAGGCCATGGCTGGCAGTTTGT
GTTGGAGAACAAGAAAAACAAAAACCCACATTCCGTAGAGAAGAGAGAGAAAGAATAAAATTATTCAATA
AAAATTCATTAGATTAGTTGTAATATACATTTTTTAAAAATCTCATTTATGGGTTTAAACATAACAATAA
AAACCTTTCCCAAGCAAATGCAATTTCATTCATGTTTTACATAGGGCCAGTTTCGAAACATAACCAATGA
CAACGATTATGCGTTCTAGCTTGCTTTTAGTGATAGAAAGTGGTACTTTTAGTGAATGCAGTTTAGGGAA
ATGTGTTTTCACACATTACAGCCCTGTTCCTTCTCAACTACAGACTGAAGTCCCCAATGATATGGGCTCA
TGATGGAAGTGAAATTCAAATTTAAGAGGACAAAATGTGGCCACTTCGCCACCCACTTATAACATATTTT
AATTATAAACCCCTGTAATTCCCGAGAGTGTTCTATTTTCAGGGAGTGATTTCCAGGGTAGTTTTAGTAT
CATGCTCAAATAAAACAACACAAAACAAAAACACTGCACGTAAGAATCCGACATGACCAGAAAAAATTTC
TTAGTATTCCAATTGGATGTGGTCTTGTTTGAAAGACAGAATTGATCTTTCAGGGTCAAAGGAGGGGAAT
AGCGTTATTTTAAAAATTAATCCACAATCAACACATAAATACCTGATCCATAAGAAATTAAAAACTAAAA
ACAAATGGAAAAGCAAAAGGCATGAACAAAAGAAGGAATAAGTCCATCCTTACTAAGGCTTTATCATTTA
GTCCTTCAAAATATGATCTGTCCAGGAAAAAATATCCATGGCCTCCTTTACCTTTAAAGCAATTGCTACC
TTTTTCTATTCCTCCTTATATTAGAAGCCTACAATTTAGCAGTCTTCAATGACCACTCAAGCCAAACCTA
TCAGCCAAGGGTGTTTTTGGAGGAATTATTAGCTGGTTATAGGTGAGCACGTTTTGGTTTGTATCCAGCT
GATGCCCCCATGATGGACCAAAAAGCAAAAATTTCAGTCATCTAGGCTGTTTTGTCTACAGTTTGCCCAA
TGATCCATAGATCTAATCTTTAACTTTTTAATTAATTACTTCTTTTTTGTTTTTACTTTCTTAAAAATAA
TTTTAAATTTTATTTTAGATTCGAGGGTCCATGTACAGGTTTGTTACTTGAAGTGAATTAATTCTCGTAA
CTGCACAAACTAGCACTCACCACAATTGTTTTCTCTGAAAGTGTATTTCATCCTTTCAGTTATTCAGGCA
AGAAACTTCAGAGTTACCTGACCCCTCTCTTTCACTCTCCACTTCCACCTGGACAAGCATCCTGTCCGAC
AGCATGAGAATCTGCCTCCTCCTCTTCACCACAGCACCACTGCTTTCACTGAGGCTGCATTTCATTCACT
GTTTCACAGGCTGTGGCAGGAGCCTCCACGCCTCACTGTCTGCTTTCAGTTCCCATCTGACCCATCTCCA
TTAGCGCTGCCTTTCCTGAGACACAGCTCTCCGTGCTTTCATGACTCCCTAGAAACAGAGAAAGTCCAGA
CACCTGAGCTGGCATCCATAGTGTTTGGCCCTTTCTATTTGTCCAAGGTTATCACTCACATCATTGACTC
TACACACACAGACACACACACACACACAGACACACACACACACACGTGCCCAAACAAGTTCTGCAGGATC
TCATTCTATGACCTCTGTTGATTCTCAAATTCTCTAGACTTTACTGATGTCTGGCACTGTGTGCCATTTG
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CTAGAGTTATGGTGCTTGTATCTGCCTTGTGTCTTTCATGGAGGATCACCAATAAACTGTGGTCCCAGAG
AAAAACCCAGACATGTTTTCCCATGTATTTGTTGAATCCAGTTTATGTTTCCATCGATTTTGTGCTGAAG
ACTCCTGTGTTACTCTCAGCAGATAATGCTGGTCATGTTCACACTCTTTCTGATGTTTGGTGCACCCTAT
CTGAATTCACGTGGACTAATAGTGTGGAGGTCTGGGAAGTGAGCCGAACTAAAAAAACTCGAGGAGATAT
TTGCTCATGAAGTTGTGAATTCAAACTTCCTCAGCAGAGATTTCCAGCATACCAGATTTCAAAGGCAAAG
CATCTAAGCCTTTCCTTAGACCCACCGCTCGAATCTCTTGTGTCCCACGCTGACTTCACATTTGGTCTCC
TTGGTTTTTAGTCAGACTGCAGAGGCCGACTAGTCTGTCCTGGGAAGGGTAAGATGCTCCTTTATCCAGC
CTGACCGGACATCCAGAGGGAAATGTTAGTTAAGCATTATTAATATGAAAAGAAAAATCAATAACACAAA
GATAATTTCCTTTTTGATTTAAGTACTGCTTAGCCAAAATAAGTATTTATTTATTGTATAGTTGCAAGCA
GCAACAAAATGAAAACAAAAGCCTCCCATTTTAGCAGACATGTTTTGAGGCTCTACTGGGTAGCAGGTAC
AATGTTGGGCTTTGTGAAGGACACAAAGATGAGTGACACGCTGTCACTTTTCACCCTGATATGGCAGCTC
CAAGCTGGTAGTGATTCTTGATATGGTAAATTATACTTTGCCTGTATTTGAATGCATTAGTTTCATTTAA
AAAATTATTTTTATGTAAGTAGAGATGAGGTCTTGCTATGTTGCCCACGCTGGTCTCGAACTCCTGGCCT
CAAACAATCCTCCCACCTCACCCTTCCAAAGTGCTGGGATTATGGGTATGTGCCTGGCCTCCTTAAATGT
ATTATAAGGTAGTCTTGATAAGCATTCTCATTTTGTTCAAAATGAGATTCAGTTGATTAGTGATGATGGT
GATGCTTGCTGGTTGTTGATCCTGTGGCTAATACGGGCTACAGAATGTCTGCAAGGGCTTTACAGCATCA
GCTGTAATATCAAAACAGCTGACCCTGGTGAGCTGGCAATGAGGCAGACAACACAGACTTGTGGGCAGAT
AAGCATGGGTTCAAATCCCCACTCTGCTTCTTCCTAGTTGTATGATTTGGGGCAAGCTTAATCAAGTCTT
GATATCTATATCTACAAAATGAGGAAGAACCGTAGTACCTATTGCACAGAATTACAGTAAGGATTAAGTA
AAACAATGCATGAAAAATGCTTTGCAAGGTTCCTGTAACTCAATACACATTAGCTTTATTACAGTATCTG
AAAATCACTTTAATTGGAACTACCATAACATCAGATTAGTGTCTGATTGTATAATCTGGGTTTGCCGATA
ATCTCAGCTTTAAACATTTTGTGGTTCTACACACAGTTCCCCAGCAGAACTTGCTGAGAAATCTTTTCTT
TAAATACTTCTTACAGGAAACATGAACTATTTACCTTTCAAAAAAAAGTCATAACCCTCTCCTTTCTTCC
TCATGAATAAAATGACTGGCACCACGTTTTGTAAAACATGCCAGATTTTGTTTAAATAATTAATATTGGCAGTCTTCAGATGAGTGGTTCTATGGTAGCATAGAAAGAGGCCTAAACTAGAAATCAGGAAACATGGGTTT
GAAACTCAGTTTGGCCACTATTGGGCTGCGTGATCCAATAGTTTGGGTAGGTCACAAAACTACCTAATAG
TTTGGGTAGGTCACAAAATATCACTGGACCTCAGCTTTTATTGCATAAAATATTAGAGGTAGATTAAACT
GTGGTTCTGAAACTCAAATGCTAGTGGGGTTTGGGGCGGTAAGACCAATGAAGGAAGCAGTTGAGTATAA
GACAATAAGGAGTAGTGGTGACTGAGGTAAACCAGAGAAGACATGTCTTACCTAAAAATCCTCTGCTCCA
ACTGACTATTGCTGATGGGATTGTGGTACATGCACATGGAGCCCTATCTTCCTCATTTTTAGGGGAAGGT
GGAATTCTGGAAGTAGATTTTTAAACAGGATAAAGACCAAACAAATATAAGTTGGCATTTTGAGACCCTT
GCATTCAATTACATCTAAGGTCTCCTCCTATCTTAAAATTCTGTTGTATTCTACAAACAGTTACGTTAAT
ATAATATAGAAATGGCATGGTTAAAGAAATGGACAACGATGGCTTGGCGCGGTGGCTCACGCCTGTAATC
CCAGCACTTTGGGAGGCCGAGGAGGGTAGATCACGAGGTCAGGAGATGGAGAACATCCTGGCTAATACGG
TGAAACCCCGTCTCTACTAAAAATACACAAAATTAGCCATGCGTGGTGGCGGGCGCCTGTAGTCCCAGCT
ACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGC
CACTGCACTCCAGCCTGGGCGACAGAGTAAGCCTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAAATGGAC
AAAGATTATTGAATCAGTTCTAACAAACCAATACATTAGGTTGTTCATTGAAAGAAACTCATAATATGAA
ACTGGCTGTTATAAGGTTATTAATACAATAATTGTAGTTCCCAATCTCCCAAACAGGTCCAAAGGGACCTTACCAGGCTCTCCCTGTGGTGGTTGATGATAAAATGATGTTTCAGTATCCCTCTCATGGAGCAAGGATTG
GAAAAAAATTGTTAGGCCCATTTTTATATAGCAAGATGGCAGGTGCTTGCATGTGTAAAATGTGATCAAA
AGGCAATAAATCTTTAAAAATACAAACTAGAATGTATACATACAAATAACTCTTGACTTCACAGAGGGCC
ATAGATTTTGCCCAACTGTGCTTCCATGGCTAAAGATTTCTGGACCCTCCTTTGAGAATTGTCTTCATTG
CCAGTTTACAAGCCACGCAATAAAACCAGGCAAGGTTTTATTAGAGACATTAGTTATTTTTGTATTGCTT
GGTGCTAAGCATTTTATAGATCTCTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCCCCCAGGCTGGAGTG
CAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCC
CGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTTTTTTAGTAGAGACG
GGGTTTCACCGTGTTAGCCAGGATGGTCTCGATTTACTGACCTCGTGATCCTCCCGCCTCGGCCTCCCGA
AGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCCTATAGATCTCATTTTTAATGTCATCATCATGG
TAACCTTTTGAGGTAGATATAATTATCTCCATTTTGCAAATGAAGCGCTGAGTCCTAAAAGATAACCTCC
TCAATGTCACGCCCCTATTAAGTAGCAGAGTTGGAGTTTAAACCCATGTCCTCACTTTTAACCACTTCTG
TCTACTTCCTCCTGAACATGAATCATCATGCTTCACTTTGCATAGTTTTGTTCCCAAAATCAAATCCCCT
CTCAAAGGGTCAACCTTTGCCATTAACAAGAGTTTTCAGGAGAATGTGCCCTAATTCCTGGAGACAATGA
CTGAAAGGAGTTTCAAAAGCCCTTTGAAAGAGTGGCCGCATTGCTGGCAAGAGCAGCTAGTTTCCCTAGG
TTGCAACTCTCATTTATATGTGTAAGCTCTGATCTCCTTGCTTAAACAAAAATAGAGAGAAAGAAAAGAA
AAAAGCAAAAGAAAAAGGCCTTATTTACTTTAAAGTTACACCTTAGACTACTGTTGTCTAAACTTGTGTC
CTGTGGAGCAGTTGACCTGAAAGAAGAGTTCTGTGCTCAAATAAATTTGGGAAACTGCACGTTCTATCCC
TGCTTGGTTATTTACAATGAAGTTACCTTGGCATAGAAACATCTCTGAAATTATTCAAAATTGTTTCACT
TTTCTTAACATCCCATAGAATATTGGTTCTATGGAACATACAGTACTTTGGAAATATATGCATGTGATAA
TTCATCTTATTTTTAGCTTAACTATTTGTACCCCACCTCATTCTAGAGAGGTTGGATAGCAAAGGATACG
CAGGTGGAAAGAATCTCATCCTAGTGGATACATTAAACGGTCTGTCTCCATATAAGGAGCAACTCAAGAC
CATTTTGTTAGTGTGGATTCGTTGATGTGACCTCTGGGAGTCAGGCTCCTCAGTAGGCTCTCTACCTGGT
CAAGCAATTTAGCACACACCCCTTCTTTAGGGACCTCCCAGTAGATCTCCATCTTTGGGAGGAAGGAGAT
GACTTCTTGCAGCTCATTCAACAGGAAAAGGCTTCTGAGTGTGTAAATATACACTGTCACTGTTTTTATT
TGGAGCAGATTTCATCACAGCTATTTTCTAAATGGCTAAACAAGCATTTCCCTGGGTATGTTCCATGGAA
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TATTCATTTTGTAGGAAGCTCAATGATAAAAGAGTCGCATTGTCAATGAGACCAGGAAACTGTATATTTA
ATTCCATTTTGAAGAGTCTCAATTTACTTAAGGATAGAAAAGGCACAGTTAAGAACCCTGATTAACTTCT
TTAACCCACTTTTCCTAAATGTATCTGCCAGTTTTTGTGTACATAAACCTCTCAACCCTTTGAAGATCGT
GCGTTCCAGGGAATACACTCTGGGAAATTCTGGGCAAGACTGTTGCAGGTTTGCAGCAGATACTAGGCAG
AGCTGATACTAAAAAGAGGGAGCTGGCTTCCTCATGGCCACTCACCAGTCCTGGGGAAGTCGGGGAGGGA
GAGAGGAAGCCTGAGCCTGGAATCCCAGCTCTGCCACTTACAAGCTTCAAATCACTTCACCTCCCTCACC
TCGGTTTTCTTTATCTCTTACGTGGAGAATATAAAACCTACATCTTAGTATTCATTTGAGGATTAAAATC
AGATGTCAAGCTGTTGAAGATGAGGCCTGGCATGGAGTAGACCCTTCTCCTTGATGTTCCAGGACTGGGG
AGATCCAGGGTGATTTTATAAACACATGGGGAGGGTGGGCTGCTGACTAGCTGTGCCAATTCCTAGAAAG
GAAGAGTTTCCACTGCTCTGGGATGAGAGATAATCCCAGGAGGATTGAGGATTACCAAAAGGGGGTTACC
ACTCCAAAAGGAGAGGGTCCATGCTCGAATGTTTGCTAGTGTGCATGTCAAGGACATCCCTGCAAATCTG
AAATCCACATCCTAAATCCTAGCCCCACCACTGACAAAAGATGTGACCTTGGTTAAGTCACTTAACCTCT
GCCAGCCTCAGTCTCCTCATCTGTAAAAAGAGGAGTTGGACTACGTATCTCTCTGGAGTACCCCCAACCC
TCAGATTAGTGTGGAACCAAATTAAGGTTATTCCAATCAATCCAGGTTGAAGAGTTGGTAATCTAATTAA
GGATCAGCTGAATTTTCAAGGTTGAGAGTCAAAAAGAACTGTCAAATAATGTACTTGTGTGTGATGCTTC
CAATTTTAATGCTTTTCTGTGTTAGGAGCATATTTTTAAATATTCAAATGTGAATTATTCACATGGCACA
TGCACTTATAATGTGTGCATTTAACTAAAGTGAATCATCAGCCTATTATTAATTATCATTTAACCAGCCC
TATTCTTTTGGATAAAGGAGAGTGTTAGTAAAAACCAAAGGGTTTGGATCATTTAAGCAAAGCCAGCTCT
AAGCAATTTGGCAAGCCCCTCCAGCTGTCCCTCCATATCTTCCAACAGCTATAACCTGTGCATCCTGTGC
TCTTTCATTTACATATACATATACATATGCAAATAAACCCATGTTCACTTGGGAGTGTGCACACTCATGT
TTGTACACACTGTCCGTGTCCTACCTAATATCCTAGATGTCCATCAAAGTCTTCTTGGGGCAGGTGACAT
CCTCACGGGACCTGAGTTTCCTTAGCAGTTAAACACGTGTTCTTTTCCTAGATCTAAGTAAGAGCTCTTC
CAGCTCTGACATTTGATGTCTGTGCTCTTTACTTAGCTATTCCTTGGCAGAAGCATTGGAGACATGCTCA
TACACATTATCTCACATAATTCTTAAAATCATCCAGGAAGTCTTTTTGCATCCTCAATCCTATTTTAACAGATGATGAAACAGATTTACCTACTTGATGTGTAAACATACAATAATAACTGGCAGTTACAAGCTTAGAAA
CCTGATTCTCTATTCTGAATCCAATCAATTCATTCTCCAAGTGACAACCAGGCACTGGCTACTCACTTTT
CCCTTCTTAATCAGAGTGGTTTTTGTGGAGTTGGGAATCATCTGGAAGAGCCTCCTAGATCATCTCCCCT
CCATAGCCAGGAAAATCTGCTCTAGGCTGAAACATGGGATGTAGGCCACTCATGGGCCAGATACAATTCT
AATGGCAATCAAGATATTATAGGTGACTGGAGAGAGTCTGAAGAAGTACATGTCATTAGAGCCAGGGTGC
CTGGCACGGGACCAAATGAGCAGTCTAGTTTGAGACAATGGGAAGTTTTCTTAGCAGGAGTCACCCTTCC
CCCAACCATTCAGCCATCTGCAGACCAGCCTCCCCGCTCCCCAGATTCCACATGCCTACTCTTTCATGAA
TGAAGGCTACAGTGCTATAAGCATAGACTCACACATCTTTAGAGCTACAAAAGACCTCACAAATGATCTA
GTCTAGTCTCCTCGCTTTACAACATAGAGAAAAGTGGTATGCTCTAGGACACAGAAGGTATGGTCAAATT
TATATTAGGCTTCCTGATTCACTCTTCAGTGTGCTGCTTCCCTGGCCTCTGAAGAGGCGAGGCCCCAGGG
CAGGAAAGCACCTCAGTGGCCCACCAGACTTAGCACCAACACATGAGCCTGCCCAGTCCTTTCGCTCTTA
TGCATTCCCGTCTCTGGCCTCTCACCCGGTATTTGGGCAGCCTTACCCTTGACCCCTTGTAGCTATATCC
TCATTCTTAGATCCTCTGCTTCTTCATTTACTTCTCTGTTGCTGGCCCTGGTTCCCTCTGAACTCTGAGC
TCCATGTTAACCCTGTTGCCTACTTTTCCGTTCCTTTTGAAGTAAATTCTGTGTGTCCTACCTCTCCGTT
CAACCAGGAACCCCCTAATAGCTTTATGACCTTGGTGTGAAAGTGTCACTTAGTCATGACCCGTCCCTACAGACAGCAGAATCTGGAGGAATTAGAGCTTAATGTTAGCATTTTACAGGTCACATCCTCTGATCCCAGAG
CAATATTAATAATGAAATTATGAAAGCTTTTTTTTAAAAAAAACAATTACAGGCAATTTTAAGAATATTA
TTCTAAATTCCCATTGAAATCAAATACGCAATTTTAAAAGATGAGTACAGAGCAAAACTTACTGGATGCA
TTACACAAAGTAAAGTTCCATTTCTAAATACTTTCATTTTTTAATCAGAAAGAATAAAAGTATATTATTG
AGCACTAAACTTAATAAGTATCCTAAGGAAATCAGGAGAAAAGCAATAAAGAAAAGATAAAATAATAAAT
TAGAAAACAGTGGGAATAAAAAAATAAATCGAAGATTTGATCCTTGGAAAATGCCAAAAAAAAATGTGCC
AGACATTTGAAGGATATCACATACTCAAATAGGGGAGATTCTGTTAATTCTGTTAATTATTCAACAGAAA
GCCTTGGGTAAATTTGGGTAAATATTTAGAAAATATCAAGGCTGTGTCTTACCTCACATCATACATAAAA
GTAAGTCCCAAATGTATTGAAGAGTTAAATATTAAAAAGAAAATGTTAAGGGGAAGATGTAGGCAATATT
TCCTTGATCTCAAGACAGGAAAGGATATTTAAAGAATGAAATCATGTCTTTTGCAGCAACATGGATGGGT
TGGAGGCCATTATCTTGAGTAAAATAACTCAGAAAGTCAAATACCGCATGTTTTCACTTATAAGTGGGGG
CTAAATAATATGTACTCATGGACATAAAGTGTGGAATGATAGACATGGGAGACTGAGAAGGGTGGGGGTG
TAGGAGGAAGGGAGGGATGATGCAATACTTAACGAGTGCATTGCACACTATTCGGGTGACGGTTACACCA
AAAGCCCAGACTTCACCACTACACAATATATCCATGTAACAAAACTACACTTGCACCCCCTAAATTTATA
ATTTTTTTAAAAAAGGATTAAAGGCAGGCCAGGCGCGCTGGCTCATGCCTGTAATCCCAGCACTTGGGAG
GCCGAGGAGGGTGGATCACGTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCGTGT
CTACTAAAAATACAAAAATTAGCCGGCACAGTGGCACATGCCTGTAATCCCGGCTACTCAGAAGGCTGAG
GCAGGAGAATCTCTTGAACCCGGGAGGCGGAGGTGGTGGTGAGCCGAGATCGTGCCATGGCACTCCAGCC
TGGGCAACAAGAGTGAAACTTTGTTTCAAAAAAAAAAAAAAAAGATTAAACGCAAAGAAATAATACATAA
TAGGAGTTGATGTATTTTGTTAAATACAAATTTAAACTTCTATATGTTAAAAATCATTAATGAAAAGGCA
AATTGGTAATCAGTAGGAAAAAACTTTTAGCATCAAAAGAAATAGGAAAAGATGAAGTAATATCCTTAAT
AAATAAAAAGTGCTTAGAAAGCAACAAAAGGGGTCAAAGGACATGATTTCATAGAGAAATAAAAATGATA
ATTTTAAATGTTGGTGAGGATATGGTCAGATAGGCATTTCCTTACTCAGAGTTGGACATGTAATTTGGTA
CAAGTCAGCAGTAAAGAACTAGAGATTTAAAAACCTTCTATAATCTAATAATGGTACTTTTAGAAATCTA
TCCTAAGTCTATCATAAGGAAATAAGTAGAGATAGGAAAAATATTTATATATAAGGATGGTTATAATCAT
GTTTATAATAGTAAACATTGGAATCGATAATTTAAAAAGTTACATCATGATATATCCATAATACAAAACT
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TACTCATCTATGGAAACTATATTTTTGAAAAATTGATTGTCATGAGAAATTGTTCATGATATAATAAGCA
AATGAAAAGAAGGATACACAATGATATAATATTACATCAATTTTATAAATACATATGTGTATATATCATA
TATGCATTATGCTTATGCATATCAGTGTCTTTGGGTAGTATGATTATGGTGCACTTCATTTTCTTCTTTA
AGCTTTTGTGTTTTCCAGAATTTCCACAATGAGCATATATTATTTATAAACAGAATTCACCAAAGTGTAT
TCAAGGCTGGGTACGGTGGCTCATGCCTGTAATCTCAGCACTTTGGGAGGCCGAGGCGGTTGGACCACTT
GAGTCCAGGAGTTCAAGACCAGCCTGGGCAGCATGGTGAAACTCCATCTCTATAAAAAAAAAAATACAAA
AATTAGCCAGGCTTGGTGTTGCGCTCCCGTGGTCCCAGCTACTTGGGAAGTTGAGGTGGGAGGATTGCTG
GAGCCAGGGAGGCGGAGGTTGCAGTAAGCCAAGATCGCGCCACTGCACTCCAGCCTGTGTGACAGAGCGA
GACTTTGTCAAAAAAAGAAACAAAAAAAAAAAAACTGGAAAAACCTCACAAAGCGTGTTCAAAATTTTCA
AACTTTCTACTTGAAAAACACAGATTGATATTATCTGGATGTGATTTTAAGACTGCTTACTCTAATTAAT
TCCTCTAAGAAAGGCATTATTGTTTAATTACATTTCTTAAATCCGTATGAGCTGAGTGGTGTTATTATGG
CTGCTCGCCAGAACGTGGTTATTATGCCATTATGTGACCTGGGACCTGTGCTGAGAGGCCACCCAGTGTG
TGGAAAAGGGTACTGAACCAGGGGTCTTGGGCCTTGCGACCTCAAGGAAAGTGTTTGGTAGCCTTCTGGG
CCTCAGTTTCCTCTTCTGTCAAATAGATCTTACCTGCTTTACTACTTTCACAGAATTGTCTAAAGACCAA
ATAAGAAAATCCAGGCAGGAGTCTATGACATGTAGGCTATTATGAAGCCAAAGATCATTATTCAAAGAAT
AAGCTAGTACCTGCCTGGAATTCATAGTTCATATAAATGATTTTTCTAAATCTCCCTCTTGGTAAGGAAA
CATACTCCCGTGGTTGCAGAAGAAAAAAGCCTCCCCTCTCCTCCCACAGCCCCTTTTCTTACTGAATTAA
TAAGTGCACAGCCCTTTGGGGAGGGTGTAGACAGATCAGGCACACCCCTGTGTCCACCTCCACCAAAATT
CTAGGGGAAAATGCCTGGCTTCTTAGGAAAATGCTTCCCTAAAAAAAGAGGAGAAACCTCAAGTGTTCCC
ATGGAACTGGGGCAGAGGGCAAATTCCGCACAACCTCTGCACAAACCCACGGGCTGGCTGCTTGGCAGGC
CTACAGGGTCCAGATCTCTGATCTGTGGCTCAGAGTAACGAGGTCATTTGGATGGTACATTGGTTTCATA
AACCCCTCCATGATGCTGCTGCTGTTGTGAGGATAGTTGTCACTTCCAACTCATATTATTGCAGACTCTA
GGCTACACGTAGTTATAGGGACAAGAAAGTCCACAGCTCCTCCACTCCCCACACCAACGGCTCCAGGCAG
ACTTGCTGCAAGGAGCAGAGACCCCTTGGTCACCACAGGTAAAGGGGACAGTGTTTTGACTGACTTGGCAAGCTTACCATGTGCAACCCTGGCTGCATATGAGTCTCCTAGGGAGCTTTTTAGTAACCCAGGTGACACCC
CACGTTTAGAATTTAACCAGAATCTCCAGGAGTGGGAACCAAGTATCAGTATTTTTAAAGCTGTCTGGGT
GATTCCAAGAGCAAGCAGGATTCAGAAGCATTGGCTCAGGTTTCAACACAGATCTAGGTATCTCTCCCAC
ACCAGTCTTCAAAAAACTTATCTTGGTGGGTTTTCCACCACAATTCTACACTCTCCTAAGCATTCTTTGC
ACGTAATTTTACCTACCATGGATCCAATTCAACCCTAAGGCATCCTTTATCCTTTAGCTTCTCTACCGGC
TGGCTCCATTTCTCAGTCTGCCAATTCCAGATCCCCAAGAAGGGTGTCGTCTTAGCCCAACTCACCTTTT
TAAACCAGGCTACTTGGGCCATGGGATGCTGGTTGATTTAGAGACTGGCTACTCTGTGGAAAGGGACAGA
GGTTGTGCAGTGTAGAACACGGCCACCCTGGTCTGCCCCAGTTCTGTTTTTTGTGTAGGTGGGGTGGGTT
GGGCACGGTTTCCCTTAACAGAGACTGTGGAATACTTTAACATATCTGGTTCAATAACAAATTATAATAA
TGAAATCAAACATATTTAGAGGAATCCATACAAATTAAGGGTCAGAGTTTCATCCTCTGTATAGAATATG
ATGTAGGAGTCTTTTTAAGTATACGTAGGATAATAAAATGGATAGCCCACTCAACTATCTTTAGAATGTA
TGTATAATTTTATACATCTTTTTCCATAGAAACTACAATTGAATTTAGCATTGAGAGATTATGGTATTCA
TTATTATCTTAGCCAGAGGGTGTTTTTTTAGCTTTTATAAGAAACTTTTAAATTGAAGTATAATATACAT
AAAGAAAAAGTGCACGTTATAAATGTACATCTCAATGACTTTTTACAAAGTGAATACCCTTGTAACCAGC
ACCCAGGTCAAGAAACTCAATATTATCATTACCCCAAAAGATGCCCCTTGTGTTCTCTTCCAATTACTCCTTGCCTCCAAGGGTAACCACTCTCCTGATTCTAGCAGCATAGATTAGTTTTTGTACTTTATATAAGTACA
GTCATATAGGATGTACTTTATTGTGTTTTGGCTCCTTTCCTTGAATATTCATCCTTAGTTTTGCATATGC
ATTTGTAGTTCTCACCAGAGGTTTTAGTCCTTGAAATGTAGTTCAACAAACATTATTCAGCCAGGAACTG
TGCCCGGGGCTGGGGACACCAAAACAAATAAGGGCAAATTCCTGCTGTAAGAAATATTTAATCCAGTAGT
CTCGTAATGATCAGAATTTAGTGTAAGGTGAATTCCTCTTTGTCCAACAAATATTTATTCAGTGTCCACT
AGAGGACAGGCGCTGTATCACAGGTGCTAGGGATAAGAAATGAACAAGCAGACAAAAAATCTAGCAGAAA
TCCTCTCTTTTCTTCCCGTGACGTGCATGGGCAAGTTCTGCCCACTAATATTCATTTCCCACTATGTCCT
GCATCTGATTTAACATAAAGGGAAGTAGCAATGGAAACTATTTCTTCTGGCAACTTGGAATATGAGAAGT
CCCTGGTCCTTGGGCCATTTTTCAAATCAGTGAGTGTGGGAGGTATAATATTTGTGTGTACCAATTTCTT
CCTTATTCCATTCTCTCCACTGCTGATGCTGCCTATACTGAATGCAATGAAAGTCTGGAACCTAAGGAAG
CCTTTGGGTGTTAGCTTACCTTGGAGTCAAGCTGAGCAGTCTTCTTGTTTTCCAGAGCCATGAAGTGAGA
AGAGACACAATTGCCAAAGCTGTGATGGAAATCATACAGCTTTGAATTTGTTTTAGTAACATGGAATTCT
AACATGTGTCACTGTTCATTAGTACTGGCTTTTCAGAGCCTCGTGAATTACTTGGGTACAAATCCATGAC
ATTAGAGGCATGAGGGATTAGAAGACAATCCAACACCACTCTAGGATTGATAGTTTAGGAAGAAATGCAA
GAAATCATCTCATTTTGTTTGGTTGGTTCATTCCTACCCCCCATTCTCCACATTTTTATGAAAAATTTTA
AGTATATATAAATGTAGACAAAATAGTAAAATTCACTCTTATGTATCCATCTTTCAGCTTCAAAAATCAT
CAACTCATGCCAATTCTTCTCTAACCCCTTGTTGTCCCCCTCCTCTGATTATTTGAAGCAATCCCAGATG
ACAAATAAATTACTCATAAATGTTCACAAAGTGAGATCTCCTAGTTTTAATTCCTGTAGTTCACAGGTTC
AGCGGTGAATTCACTAAGCTAGTTAGTGGTACTTATATTTAATCCCTGGCTTCAGAAGTAAAAGTGATAA
GCTTTACTAACAGAATTACTATTATTATTATTACATTATGACATAATATAATATATTCTTGTACTGTTTG
GCCTAAAACTACCTCTTTTAAGCCTCTCATTCAGTTCTCCAAGGAGTTCAACAGGGTGTGGGATGGCTGA
TTGATGTTCTTTTTCATCAGTAATTTCTAAACCAAATCCTTGTGGATTTTGAAATTGCAAATATATTTGT
CCAAGTAAAAGCTTCAACTATTTGGTAATAAAATGGGTCTAAGACTCTTCCCAAACCTCATGTTTCCCAT
TTTCAGTCTGTGTGCAAAGGAGGAGGTTGGCTGTTGTTCATGGAGCCAGTGTCAACTGCCTGTCTGTTAC
GAGATGTCACAGCACAACCAGGCATGCAGCTTACTTTTTTTTAGGTTTCCCAGGCTCAAAACCGCAAAGT
ACCATTGTTTTTGCCAGTTAGAACACTCCAGAGGTTTCTAGAACAAGCAGAAAAGATTGTTAGTGCCTTT
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GTCATGAAAATATGTAAAATGTTGCTTTGGCTGCTTTGGCTATCATAGCTGCTCTGATTGTATCTCAAAA
TGTCACCCAGGGTATGTGGCAGTCATTGTGAGGAATCGGGCACCAGGCACCCCTTGATGAGCCTTTGATG
AGGAGATGATTAGGAGTAAAAAAATGCTGCATAGATTATCTGCATAACTAACACTGTAGCAGACAGCCAT
GCAGACATTTTTCTGTATACAACTCCCACTCATTTTTCTGAGAGATAAAAGCAGCCAAGATTGACAATCT
GTCAGTTTCACCATTTTCATTGTGTACTTTTTCTGGGCAGGTTATTCACATCGAACTCCTTTGATGTGAT
CAGTGATGATGCTTTTATTGGTCTTCCACATCTAGAGTATTTGTAAGTAAAAAAGCTTTTTTAAAACATG
ATGATTCAGGACAAGTACTCTCAAGTTCCTGTAACTGTTTGACAAAAAATATTATAACTTATTGCAGATT
CATAGAAAACAACAACATCAAGTCAATTTCAAGACATACTTTCCGGGGACTAAAGTCATTAATTCACTTG
TAAGTATGAATGTTGCTATTACTTTTTAAGCTTGCTAATGGACAATGCAGTTTGATCACCTGTGGTTAAT
GCACCTACTTTATGAGTGTCCATAAAAATTTAAGAAACCCAAATGACTTCTCTCCATGCACACTTGCCAT
CTTTCCCTGTCATCTGTCAGAGGGTGTTCAATAAATTGATTACTATTAATATTTTTATCCAAAACCAACC
ACAATTAGAAAAGCAATCTAATGCAGGGAAATTGTGTGCCTGAAATAACTTCTTTTATTATCTACATCAT
TACTTGCTTCATGGATCATTATGAGTTGACTGTATAATTTGATATCAGCTTTTTTTCCCTCTATAAGCCC
TCACTTTATATACATTTAAACATAATATAGCCACAGGCGATGTCTTCATAGTACCTGATCAACTTGTTTA
TCAGTGAAATATTTAATTACTCAATGGATGATTACAGCTAACAGCAGTTGTTCTTAACAGGGAACAATTT
TGTCTCCCAGGGAACATTTGGCAATATCTAGAGACATGTTTGGTTGTCACAACTGGGGATGTAAATGGCA
TCTAGTGGGTGAAAGGCAGGGATTCTTCTACTGCTTAGGACAGCCCTTCACGACCAAGAATTATCCAGCC
TAAAGTGGCATCGTGGGCAGGTTGAGAAACCCTGAACAACAGGACCCAAACAATTTGTTTCTTCTAGCCT
CCCTCACCCTCTACAGACAAACACATTCACACACACACACACACACACACACACACACACACACAGGCAC
ACATGTGCATACACACACACACTCACACACACACTCTCACATACACACAGATTATTTTAAGGAAACTAGA
AGAGCATGGAAAGAAAAGGCACTAACATTTACATCACTTTTCATCTAATCCTCTCAATAATCCTGCCAAA
CAGGCACAATAATCCCTGTTTCAGAAATGAGGAAACAGTCTTGGAGGGGATATATGCCTCGTGAGCTGAT
TAGTTACGGAATTATGAGAACATCTACTTAATTGTTGAATTGCAGTGACTCTTCATCCTTTCAACAGCTA
TTTCTCAATCTACCTAATATGTATCTTATCAGTTCTAGATACAGATGCAAGAGATCCAAGTGTCATAGTCATTCTGTCAGCTTTAACCTGTTCTCTCATCATACTTCATTCCCAGCTCTGCTCTAGGCCCTAGGATGCAG
CAGGGAACAAAGGAGACAAAAATGCCTGTCCTTGGACTGAGCCTGATTTCCAGTGTGTCCACGCGGTTGT
CACTCTGCCTCCACCAGGCCCCTTTCTCTCCTGTTGCTTGTTTTGTAGCAAAGAGAAGCTAATAGCCAGA
TATATTTTACAAAATCATGCCTTTCAAGGCTTCTGTATAGAGTTATTGTAATAAAAAAACAGTGTTTGCA
ATACTACTCTTCATGTCAATGACATGATATGATGCAAAGATGGCTGTTTACAGAATGAATGCTATGCAAT
TTTATCACAGAGCTCAACACTGCCAAACCTCATTTTTCAGACAACAAATAAACAAAAGAAACAAATATAT
GGAAGGAGAAATGGAAATTCATGACCTCAACTTGAAATCCACTAGATTCACATACATCCCAATCCACATG
GCCTCTGTCCAGTGCTTAGCATCATGAGAGCTGTAGGGAGGATGCACAGCCCAATTCATCCAGCTGTGTC
TCCTCTCCAGCCTAAAAGCCTGTGGTTTCTCTCAGGCTCCATGCACAGAACAGGAAAAAATGTTTCCCTG
TCTTGGAAGGAAGGAGGGAAGGAAAGAAAGAAGGAAGGAAGGAAGGAGGGAGGGAGCGAGGGAGGGAGGG
AGGGGAGGGGAGGGGAAAGGAGGGAAGGAAGGGAGGAAAGAGGAAAGGAGGGAGGGAGAAAGAAAAAGAG
GAAGGAAGATGAGAGAGGAAGGGAAGGGGGAGAAAGGAGGGAAGGGGAAGAGGAAAAAGGGAAAGAAAAA
GTCTGTTTGACATCCTAGTGTAGGACACCCATTTTGTTTACTGGAGCCTATGATGTGTATCAAATGAAAT
GGGAATTTAAATATGGGTCTTAATGATGCCCTTTCTTTAGCAGTATGGAGCCTGTAAGAGAGAGAGACTG
ATACAGAACACGCTTAACATTCAGAAAATTTCAGGTTCGAGGAACACCAAGGGCAGCCTTCAAAGAGAGGCATGACTCTTAACAGGCAGTGAAAGAGAAGTCCCACCTCTCTGAGCTGGTGCTGGAGGTAGGAAGGTGTT
ATGAGGGAACAGGGGTTAAGGCTGTGGCTAAATGAATATGACCCTTAGGTCTCTTGTATCTTTAGCTAAC
ACTTATTAGGTTGACTGATACGGCATTGCCAATGTTAGGCTGTTTTTTATCTACAAAAATGGCAATGCCA
TATGGTTCATCTTAAATAGTTTCTAAGATGTGACACATGCTTTACAAGGAGTAGGGCCTACAAAGATGAG
TAAGATCTAGTCCCACCTTAGAGAAGCTCAGGCTAGCAAGAGAAATTGGACAAATATTTTCTCACTGAGT
GCCTTTGTCCCCAAGTTATGTTCTCCTTTCAAATTATGCTATTCTTCATGGTACAATTCCTTCCTTCCAT
CCTTCATTCTTTCCTTCCTTTCTTCCTTCCTTCCTTCTTTTATTCCTTCCTTCTTTCCTTTCTGTCTTTC
AAGGAGAGATGGAGTAGGGAGGATCTGAAACCCAAATTTCCCTCTGCCGGCTCAGTAAGTCAGGTTCATT
TTCCATTATTTATGGCGTATTAATAAATCTGGCATTTGTCTGAGCCATTAGTTTCCTTTTTAAGACATTA
GGCTTCAAAGTGCACTTTTCTCCACCTCAGATCAATCCTTCCCAATCAAGGCAAACATTCAAGCTGTGAG
GAATTAGTACCTCACCCTCTAACCTGCATGCATTGCAGGAAGAGGTTACAAAGCTTTCTCATATTCTTGA
CTTCATCATAGTCTCCTGACGACCCCGTGAAAGAGACAGGGCAGTAGCACTAGGTTCATAGATGAACGAG
CAAGTGGAGGTATACCATGAGTTGAAGCTGCTCCCCAGTTACTAAGTGGTAAAGCCAGACAGCTCCCACC
GTCTTTGATGAGACGTCCAGTGCTACGTCCACTGTGCCAGTTACCGCAGGACCAGATAGCTTTTATTGAG
CTGGCTGGATCCTTCCATGGGACATGATTTGAGGAGAAAATATGACTAGAGAAGAAAGAAAAGATCCTGA
AAACAGGAAACCTACCCTCATATTTCATCTCAAAATGCAGATAGTTGGGATTAGACGTATACTTTCAGGT
CCAGCTGGTTCCCACTCTGGCCTAACATTAAAGCCACTCCCTTACCTGCGCCTTTATATAAATTTAGTTC
ACGCCTAAGAAACAATGCACTTTCTCACCTTCTTATACAGAGATGTCAGTAGATTTCTCTTCTAAGAGAC
ATTTACAGATAACTTAAAAGTTATTATAGGCCGGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTTGG
GAAGCCAAGGAGGGCAGATCACTAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCATC
TCTACTAAAAAATACAAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTCTGGAGGC
TGAGGCAGGAGAATGGCATGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCACGCCATTGCACTCC
AGCCTAGGTGAAAGAGCAAGACTCCGTCTCTAAGAAGTAAATAAATAAATAAATAAATAAATATAAAAAA
GTTATTATATATACCTGGCTATCAGGCGAGATCCTCCCCTCCCCTGCAAATTAACCCTTAAAACCCTGCA
AATTAACCCTTAAAAAGGGAGAGAGACTTCTTAAAGTTAAGTCCTTTCAAAGCCTGTCAAATGTTGGGAT
TCTCAATTACTTTGTTTTGAATCATTGTTCTAATGTTATGCATGTTTCACTTTAATGTTTGAATGGTTTG
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TATATTTTAGTAATCTTTTGTATATTTGAATTTTTCTGATGAATATATGTTATTTTGGTAATCAGGAAAA
CATGAATAAAAAATTAGTTTATGAATAAAAAATTAATTTATGGCCAATGATGACAAAATCTTCAAACATT
ATGTATTGGCTTCTAGTAATACCTATGAGTCTTTAGTAATGATTGCTTTGTGTGCCATTAAGTGTCACTG
TGGCTAAGGCCCAGTGGAGCCAGCATTGTTTGCATGCATATATATAAATATTTGGAGAAAATTATCATCA
ATCTATATGTATTGTAGAGTATCCAATGGTTGCTCAGCACTGAGGGGGTACAAAGGACTATATAACAGTC
CCCAAACTCAGGATGCTTGTGTGTTCCCAATCAGTTGCACAGGATGTCTTTGTTTTAGCCTTCACATTGC
CTTATATGTAAAGAGGTAGTGCAATGTAGCAGCTAAGAGGGTGATCTCTGCCACCAGACTGCCTGGGTTC
AACTGTCTCTCTGCCAGCTCAATAGGACAAGTTTATTTTCCATTATTTACTACTTATTAATAAATCTGGC
ATCTATCTGAGCCATTAGTTTCCTTTTTAAGACTTTAGGCTTCAAAGTGCACTTTTCTCCACCTCAGATC
AGTTCCTCGGCTTTGCACCTTAACAGCTGTGGAATTTGGGGCAGGCCATTTAGCTTCACTATGCTACAGA
CTGGGCATGTAAAATGGGGTTATAATAATAATCTCTTAAAATGGGATGGGGAATAACAAGGCATTTAAGA
GTATTAGTGCCCAAGGTTGTCTTGAGATTAAGTCAGTTAATAAATGCAAAGTGCTTAGAACAGGGCCTGG
TATGTAGTAAGCACCACTGTATAACTAAAACTCACTGCCCAACCTCCATTAGTCCTGGATCAGAATTCTA
AATGCTATAGTGTATATACCATTTAAACATTTTCTGTGAAATTTAAGTAACTACAAAGTGCTCAGAACAG
GGCCTGGTATGTAGTAAGCACCACTGTGTAGGAAAAAACTAAAACTCACTGCATAACCTCCATTAGTCCT
GAATCAGAATGCTAAATGCTACAGTGTATATCCCCTTTAAACACTTTCTATGAAATTAAAGTAACTGCAC
TTGCACCGCCGCAGGTTCAGAGAGACACAAACCCAAGCTGAGAATCTGCATTGCAGGGGGGCTGGTGCAC
CCCAGATGGCTGTGGGCGATGCTTTCTTAGCAGCAGAGCCCGGTGGCACTGAAACAAACGCGGTGTTTGA
GCCAGTCTGGTCTGCCTTAGAGAGAAGACTTTCCAGTGGGTTCCACAGTCACAATCGGAGGTTTTCTTGG
GTAAATGATGAAAACACCAAAGGGCAGGAAATGGTCATCATTTCTGTGAAGAAGGAATGGCCGTCTGCCT
TTGAGAACACTTGACCTTACTCAGCCAGTTTCAAGGTAACTAGACATTCAGCTGCGCAATATCTCAGTTG
TTTTAAAGAATGTTTCTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGT
GGGCGGATCACAAGGTCAGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAAT
ACAAAAAATTAGCTGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCTTGGGTGACA
GAGCGAGACTCCGTCTCCAATAAATAAATAAGTAAATAAATAAATAAAAGAATGTTTCTTAGGTGAACTT
TGAACCAGGACCTAGAGAATGGTGCTTAGTTGAAGGCAACTTTAAAGAGCCTCCACGTTGCCTTGGGATT
TCTACCACAGTGGGGCTGTGGGGAGGGAGGGTCCTTCCTGAGGTGGGGGTCCACACCAGCTGGTGGGGAC
TGCACTAGTCACTCACAGGGCTTTGAGCTTTCTCCCCCAGTGCCTTGGCACAGGGGGCCTCAAAGGAGCA
TCCTCTGCTCTTTTCTTTGCCTAGATATGTACGCGTCCTCTCGTCTACTCCAGCCTGCCTCATTCATTCA
TTCATTTAAAAGTATCTATTAGGCTGTGTGCGGTGGCTCATGCTTGTAATCCCAGCACTTTGGGAGGCCA
AGGCGGGCGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTAC
TAAAAACACAAAAATTAGCCGGGCATGGTGGCGTATGCCCGTAATCCCAGCTACTTAAGAGGCTGAGGCA
GGAGAATTGCTCGAACCAGGGAGGCGGAAGTTGCAGTGAGCCGAGATAGCGCCACTGCATTCCAGCCTGG
GTGACAGAGTGAGACTCCATCTCAAAATAAATAAATACATAAATAAATAAAAGTATCTATTGAGGGCTTA
CTTTGTGCCAGGCACTATGCTAGCACTACAGATAATGGAAAGAGAACCATCCTTCTAGTACTCATTGCAG
AATTATCCTAGAAATAAAAGAACATTGATTAAATGTTTCCTCAAGTCTCTCATTGACTGTGTCTTCACCC
CTCTCCCAATCGGCTCCACCCCACCCCAGTCAGATATTCTAGTGCCACCTAGTGTGACCTCCATGCCCTG
GAAAAGCCTGTTGTCAAACTCACTGACCCCTAAGTACGTGGCCTAAAGTATCACCTATCCTAGTGTCATCTATTAATTTTAAAGATGAAGCCATAGCCTCTCAGTGAAAATGACAAAGCTGTGATTTAAGAGCAAGAATA
GGACTTGGAGATCATTCTGACCCAGTGATCATTCACTTTATAGAAAAGGGAATAGCCTGAGCTCAAACTC
AGATATCCACTTCCCTGTCCACGTCACCCCTGTACTCTGTGGCTGAGTTCTGGGCCCTAAAGTGAGTCTG
ACTGGCAAGGGGTCCACTTTGGCCAACACAGGAGCCTGGTACTCCTTAAACCAAAACATGTAGAAAGTCT
TTTTCCTGACAACTCTGGTGGCTACCTGGGACTCCTTGCCTCTCTGTCCTTCATAATTTTTCTTCCTCCT
ATTCCTAAGAATTAAGAATTCTTATATCTAGTATTAAAATTCAGCTCTGCTTAACAGCTCTTGGCTAACA
GATCTTTGCAGAGGAAGGAGGGTCCCCTACTGCAATTCAGGGTGACACTCTCTCAAGTCGTGACACTCTC
TCTAGTCATGACACTCTAGAGGAAAGAGAAGGACTAGACACTCTGTGGGCCAGGATCCATAACATGATGT
TCCAGAATCACTTGCTTTTGATGGGCTCTGTATTAATGGCTGGAAGAAAACATGACTAAATCTTAACAGT
GGTTACTTCTGCTATGATAATTATTATTTCTCTCCTTTTTTAAAAAAATAATTTTTGCACTTTCCAACTT
TTCTTGAAGTGAAGAAATAATTATTATTCCATATATATGTGCATATGTAGTGTGTGTATATGTGTGTGTG
TGTATCAATAAAAGTAAAAGATGGGACTTTTAAGAATACCAATGCATAGGATTATCCCTACTAAGAGAGG
CAGAAAGAATAGATGATCTCAGCTTCCTGAAGCAAATATTTTAAAGTGTTTAGATATTTAATATCACTGT
TTAATGACAATAACAACAAAGAAAAAGATTAGTTTTGTGGTCTTAACACATAAGGTTTAAAAATTCACCT
GCAGATACAGTTTTTCCTGGAATCCATTACAAAGATATGTATATAAAAATATTAGTAGCTACATGTGTTA
ATTCTCACAATAAGTGAAATTCATATCCTTTACTCAGTTTTGCAGATGTCAAAACAGAAACCCAGAGAGG
TGAAATTAACTTGGCTAAGGACACATTCCTAAGAGTGATGACGTTCAAATTTATTCCCTGGTGGATTTGG
ACGAAGTTGGCACTTAAACCACTATACTCCCCTAAGTGATGCAGGAAAGAATAGCTACAACCAGTTTTAA
AAATACTTAGCACGTATAGCAACTAGAGCTTCTGTTGAGGAAAAGTTAATAATAATATTATTATATCATT
ACTCTGTGAAGCTGGGAGTGGGATGAAGACAGAACTGGGAAAATTTTATCCAGGTATTTTGCTTTCTGGT
AGCAAAACTCGGTGCAGAGGTGGAATCTGAAGAATCAAATAATCCTAATATCAACCCTAAAATAACCCTA
ACCCTAACCCACAAAGTGCTATCTCAGTCTCTCTAGCTGTTAAAATTCCCTGATAGACACAGGATCTCAT
TCTACTTACCCCTTTTTTAATGACTAAATGCTGAGGAGGCTTCAGGGAACGTCGCGTGACTTGCCCTTTT
TTTTTCCTGTTGCCCCTGAGCCCGGTGCCCTCAGCAGCCCTCCGCTGCAGCAAATCTCCCTGAAGCCCTC
AGATGCCCATGATGATTTGTGGAGGCAACAGGCCCTCATCACAGCTGGCTTTAAGCTGGCGCAAAGAACC
ACAGCGGTGGCTTCAAGCCTCGGCTGCCCTGTAGCCCCAAACCTCCCTAAAGGGTGAGGGCCTGAAACCG
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CATGAGAGTTTTCTAGGAAACAGGCAGCTCCCCGCTGCAGGAGGTCTTGTGAAAGACATTTGCATGACCT
GACCACTCAGGCCCCCGAGTTCGGTAATTCCTAATCTAACCCTGTAGGTAGCTTTGGAACTTGACAAATG
CAGCCAAACGATTGATTTCGAATGACTGAACCCTCATTGGACAGAACCATAGATATATACAAATACTAAG
CAACAGGATCCTTTCAAAAAGTCAACTTTATTCTTTGTTTCTTCTGATTATAAAATAATAATACATGCTT
GATGATAAAAACTCACAACATAAATATGTATTTACACAGAAAAGTGAAAGATTCCAGTAACCCTACACCT
ACCTCATTTTTAAAATCTCCTACAAAATATTCCGTGTTACATATGGACCATAGTTTATTTACATGATCCC
TTATATCTCTTTGTTGTTGTTGTTGTTGTTGTTTTTGAAACAAGGTCTCACTCTGTCACCCAGGCTGGAG
TGCAGTGGTATGATCATGGCTCACTGCAGCCTCAAGTTCTAGGCTCAAGCCATCCTCCAACCTCAGCCTC
CCAGAGTAACTAGGACCACAGGCACACACCACACCCAACTAATTTTTGTATTTTTCGCAGACAGAGGATT
TTGCCTTGTTGTCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCTGCCTCCCAAAGT
GCTGGGATTACGGGCGTGAGCCACCATGCCCTGGCAACCTGTTACATTTTTTGCAGAGTAATTCTCAGGC
TCTGTCAGCATTGCTTTCCTAAGTCGTTCTCTGCCCAAATCCCTCTGCCTACTTTCTTTTTATCTAAATG
TAACCTGTCACTGGAGCCTCCCAGAGACTTAGGGAAGCTGTCTGAACTCCAGCTCCCTAGCCTTGGATGT
CTGGAAGCCTCACTCTCATTTCTGAATCTTGCTTCCTCTTGAGTCTGCTTCTCTTAGTGAATCCAGGCAG
CCTTCTCATGCCCATCACTCACCAAACCTAGACATGAAGCTTCATTCTCTCTCCTCTAAGAGCAGTTCAT
TGTGGGCAAGGATTTCATTGAATTTTTGGTAGCGGAGCATCAGAGGGTTGACACTGGGTTCAGCGAATCC
ACCCACCATTTCTCCCTCTGGCTCCCCTGCCTCCCCCACCCTCTGATTCCCAAGGCAAAAGCCTGTCACA
AGAGGTTCTCAGGAAATTTAATGCCTCATTCCACAGCCCATCGGGCCAGCCTGTCCTTCTCAGCCCCATC
TCACAATTCTGGTGAATTAGAAGCCCTCCATCTTGTCATGCAAAAATACTGCCTCTCCATTCTGGAAGCC
CCATAGCTCCAAGTCTGCAGCTCTGTTTTGCCATCTGTTCTGTGGTTAGCTTGCACGTGGATCATGTGAG
GCCTAAAGCTCTACTCCTTTGGGCAGGAAGTAGAACTTCCAGATTCACTCATTATTTAAAAGAATCCCAC
AGGGTACAGTGGCTCACACCTGTAATCCCAGCACATTGGGAGGAAGAGGCATGAGGATAGCTTGAGCCCA
AGAGTTCAAGACCAGCCTGAGCAACATAGCAAGACCCTGTCTCTACAAATAAAAAAAACTTAGTTGGGCA
TGGTGGGACACACCTGTGGTCCCAGCTACTGGAGAGGCTGAGCCCAGAGGATCACTTGAGCCAGGGACGTTGAGGCTGCATTAAGCTGTAATTGCACCACTATATTTCAGCCTGGACAACAAAGTGAGACCCTGTCTCAA
AAAAAAAAAAAAAAAAAGAATTCCCCTTGGACAGTAAGACAAGCATGGTGCCTTCTCCTGTATAGCCCCT
ATTGGCAGTAGTAATTCAGGATTTGACTGCTTAATCATTGCATGCCCACTGTCCTGTGACTCAGCCTCCT
CTAAATTTATGCTCTGCAGCCAGTTGCAGTTTTTACCAGCTTCAGAGGAAGGGACATCCACTTAGAAGTT
AGTATGATAACTTTAAGCCACATTGTGCCAGAAAATAAACTGAGACACATAACATGGGAGTGACTCTGGA
CTGGTCCAAGACATCAGAAAATCTCTTCATTCAAACACCAGTCAGTAAGATGAATTATGGAGACATTCTC
TTGAATAGTCTTCCTTAGCAGCATTTTATTAATTTTGCTGTATGTGGACAGCCATAGCAGTTCATTCATG
TGGTCTGTTTCTAAACGTTGTTTCTTGGACAACATACGTACAGAAGCTGTTCTCTTCTGACACCAGCCAC
TCTACTGAGAGTAGTTCAGACACCTGCACCATCCTTGATTATCTCATTTCCTTTTTTCAATAATCTTATG
AGATAAGGTATTATTATCTTCACTTAAAAATGAAACAACTGAATTTCCAAGAAGATACATTACCAAAGTC
ACACAGCCAGTAAATGCTGGAGTCAGGATTCAAACATAGCTCAGAATCACTCCAAAAGCCATGCTCTTTG
TCACAATTGGACCGTCATTGACAATGGAACATTCTGACTCAGTTCCTATTCTTGCATTCCAAGGTTCATT
GAGAACCATTTTCCAAACTAGCAGTAATTTCTAAAACCTAGAAAAACAACATAACTAACTTAAAAATAAG
TTCTAAAGTTCATGAATGTTTGCACTTGAGAAACCTTATATTTAATTAGTGGAGGTAGAAGACATAGACT
TTTGAGAATGTTTTAAAGGGAAGTTGAGAGAATTTTCAAGGGTTTAGAGGCTAATGGTATGGGCTCTTTAGTTTTAGTTTAGTTTTTTATTTTTATTGTGGAAAAAAAAAACACCTCTAAGAAAAGTTTATAACGTGTAT
ATATATGGTGCTGGTTAAAAATAGAAAATTACACTACTTGGTGACCTTCCCCAGTCATACAGCATTAGCA
CTGTGCTATGTCTATATTTGTGTACTAGGGACACATTTCCCTTTCCTTGACATTATCAGGACAATTTTTT
ACTCATTAACCTTTATTAGAATCATTCTAGTGATTTACGGAAGAACAAATAGAAAGGGAAAGGGAAAAAC
ATTCCTGTGATCACAGGAAAAGAACCAGAAGAAGGAGAAAGAGGGGGATGATTAAAGAGAATAGATGGAT
AGGTTTTTATAAGAAAACTTTTTTCTGAGGTGGAATGAATGGTGCTAGAAAGGAAAAGGAGGCGTGGGCT
TTAGAAAGGAGAAAGGATGTACTGGGGAAGAGATAGAGCTACTGGCACTGTGGGTTGGAGGTTTGGTTGC
TCTCCGGAGCAAGCGAGGAGGAAGCAGGCAGAAGGGGCAGCCCAGGCAAGAGGAGGGGGCGCATTTTGGA
GATGGACACTCACCAGTTTGGTTAGTCATCATTTGGGAGATATCCCCTAGATTGAGCGTCTGAGAGTGTG
AATCTCTCGTGTTCTGTTCTAAATGGAAAGATCAATGCCCAGGAATCATTGTTGTTTTTAACCAACATAA
AGTGTTGTTTAAATATTGAGTGCACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACTGA
AGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAACAATTAG
CCGGGTATGGTGGCGGGCACATGTAATCCCAGCTACGGCAGGCTAAGGCAGGAAAATCACTTGAACCCGG
GAGGCAGAGGTTTCAGTGAGCTGAGGTCACACCACTTCACTCCAGCCTGGGTGACAGAGCGAGACTTTTG
TCTCAAGAAATAAAAGTAAATAAATATGGAGTGGGTGTTGAAGTGAACAGGTTAGGAACTGAAAGGACAA
TAGCAGGAATCTGAGTAGTAGTTCAGAAGAAAAAAAAAGGACCACAAGTCTTTTAGTAGGCTGGAAATGA
CAAAAGAGACTCATCACTAAGCTTTATCATTAAATGCCTTTGTTTAATTTATCACTACAGTTTACATCAC
CTTTTTTTTTTTTTTTCCAGGAGCCTTGCAAACAACAATCTCCAGACACTCCCAAAAGATATTTTCAAAG
GCCTGGATTCTTTAACAAATGTGTAAGAGGACCTAAGAAATCACTGAACAATTAATTAATTTGCAGTCAT
TAACAAGGAAGCCTGGTATTGATTATTATAATTTTTAATTGGCTTTTAAATTAAAATTAGGATTTTTAAA
TCTAAATTTTAACTGGCCAAAAATTTAAATTTACATGGACTAACATTTGAGTCTTCTATGGTATTTATCA
TTGGGAATTCTGAATACATGGCACCCAGGCATTCCTTTGACAAAGTGTGTGTCAATACGGCAGGGAGCGA
TGATAAAGGACTTTGACGGGGTGGGAAGAGACCCGGCTAGAAATTTCAAAATCCCTTTTTTCTCATGAGG
TCCAGGAAATAGGGCTACAAAGGAAAAACATAAAGGAGTCTGGGAAACTGACAGAATAAAGATGAAAGGT
TACATCCTTGGGTTGGTCAATCAACAGAGAAATGGAACAGGAAGTGGGGGAAGGGAGAAAAGTTTGCCTT
TTTTCTCATTAGACTGAACAACAACTCTAAGCTTAATCCCCAGGAATTTGGCTTAAGCCCCAGGAAGGGA
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ATGAACTTAATTATTTTTGACCCTTTTTCAAACAAAAGAGCTTTCAAACTTTGACTTTTAAGCCTCCGAG
TGAAAGATCTTTGCAAGGAATTTGTATATTTTGCTGTAAGCAAAGCAAGTAATATATGCCTAAACTTCTC
AAAAGCAATTCAGCTTCATTATTTGCCTTCCAGAACATTAGAAAGGTATTTAAATGTCATAAGGTGGAAG
ACAGGAACAAATGAAAGGATATATGAAAACAAAAGCTTTTTTAAAAAATTATTCAGGTACTTGTCTGTAG
AATATATATTCAAAACAACTTTTCTCCAATAACAAACAAAAAGAAAATCTGAGTCAAGTACTTTCTTCCA
AGCCCAGTATTTAACTTCAAATCAGTAGCCTAATGAAAAACTTTCTTTGTTCCTTGCAGTATTTCCCCAG
CCCCTCCTCCATGTCTATTACCTCAATTCCTGAATGATATGGTTTAATTCCAGGAGAATGCCCAAATCAG
GATTCTTCCAAGAGAGTCCTGGACAGACCATAGTTATCCTCTCTGGTTTACAGTAGCCTGAAAGGTTGCC
ACTCATTAGTGTGGGTCAGAGTTCTCTTGGGAGACTAGGTCAGTTCTGGGAGTGTCTTGGAAGTTAGAAC
ACACTCCATGGGTGACGTGGGATGTAGCTCATTGGGGGTCCTTTACCCCATTTTTGTGTCAGTCTATACC
CTACACTAGTGAAAGACAAAACAAAAAAATATTGAAATTGGCTCAGTCTCTCATGGGAATCCCAAGATGG
GTTTAGCCTTTTGGACCTACTCTAATATGCCCAAATCAAGAATTATCTTAGAAGTACAAGGATCCATGCC
AACTTGCCTTTTAGTGGATTTCTTGGCTTTCTTGAAAGTATCCTCTAAAAAACATTTTTAAATGTTTGGG
CGTTTAAAAATTATTTATGTGTGGTGTGAAGAGTAGGCAGCACCTATCTTAAGAATTCTGTGTGACCAGG
AAAGGAGGTGGAATTCCTGAACAGAAGCAATGCAAATACACAGAGAACTTGGTGAGTTGGGGTCATATGT
GGATATGTAAATGGTCTATGCTGTATAACTTATTACAGGCATGAGCGATTGTATGCCTGTGTTAACTCTG
CTGTGTCAAAGTCATTTCCTATTTAAACTGAATTTGTAGACCACGGAAGAGGATCAGGATTAATTATGTC
TGTGAGGAAGAAGAAAAGCAAATAGCTCACTTGATTAAATACATTACAATAATCACTACATTCTGTCCTT
TAGACCTGTGCTGTCCAATAGGGTAGCCACCAGACCTTATGGTCACTGAGCACCTAAAATGTGCTCCTAG
TACAACTGAGAGACTGAATTTTAAATTTTACTTAATTTTTTAACAGTTAAATTTAAATTTAAAAGCTGAT
TCTCAGCTCAATTATTGGAAAATGTTAAGTACGCTTGGAATAATTTGGGTATATACACCTATTTTTTTCA
ATTATGAATTTTATGACATCTAAATATAGATCACCTATTTCTGGTAAAATTTAGCATCTGAATTGAGATA
TATTGTAGGTATAAAATACACACTGGACTTCAAAGACTTAGTATAAAAAAGGAATGTAAAATATCTCAAT
AATGTTTATATTGATGATGTGTCAAAATGATAATCTTTTGTATGTATTGGGTTAAATAAAACATATTATTAAAATGAATTATACCTGCTTCTTTTTACTTTTTTAATGTGGCTATAGAAAATTTTAAATTACAATTACGG
TTCATATACTGTTTCTATTGACAGCACAGCCCTAGACTAAGCCGCTTTGGAATTCAAGAGGGAGTAAGTG
ATGAGGTTCCATTGACTGGGTAGTCTTCAAGTGTGCATGGTGCTAACTCTCTGAGCCCAAAGTGAATGAG
TGGTCAGTCAGGTTCCAGGCAGGTTATAGGGCAGGATGCAACGCCGGGTAAGGTCATTCTGCACATGTTA
ATTGTTGATGTAGAACTCTTTCCTGCGTGGGTAGGGCCCTTGTACAGCAAAAGCAGCTGAAGTTTGTCTT
TCAGGGACCTGAGGGGTAATTCATTTAATTGTGACTGTAAACTGAAATGGCTAGTGGAATGGCTTGGCCA
CACCAATGCAACTGTTGAAGACATCTACTGCGAAGGCCCCCCAGAATACAAGAAGCGCAAAATCAATAGT
CTCTCCTCGAAGGATTTTGATTGCATCATTACAGGTAATGTACTCATCATCATTCCACCTCAAAAAATTA
AAATAAGGGCTACCTTTTTTTTTCATGTGCAGGAACTGATATTTTTTATATCTTAAAAACTAGCTGAGCA
ACTTAATTTTAAAAAAATTATGAACCATTGACAATGCTTCATGTGTTTAAAAGTAAAATGGCCATTTTAC
TATTCTCTGAAATAAATGTATTTCTTGTGAATATTTAAGATCTAGCCAAGGAAAGAGGTATTAGCTCACA
GTTACTTATTATTTCCTATTTTTGCAGAATTTGCAAAGTCTCAAGACCTGCCTTATCAATCATTGTCCAT
AGACACTTTTTCTTATTTGAATGATGAGTATGTAGTCATCGCTCAGCCTTTTACTGGAAAATGCATTTTC
CTTGAATGGGACCATGTGGAAAAGACCTTCCGGAATTATGACAACATTACAGGTATGAAAAGCCTAATGA
TATTTTGAGTGGTAATTTAAACTGCTTCAGCCAAGGGCAACAAGGAAAGATGAGTGGTATAGGGGAATGCTTTAGCATTTGAATTCCAACTCTACCATTTGTTAAGTGACCTGGGATTGTTCTCTAAGCCATAATTTCCC
CACTTGTAAAACGGGAATAATATTAATACTTAACTCACAAGGTTGTTAATAAGATCATGTGAACACATAT
TCAAGAAACTTAGCATAGGGTCTAGTATAATACATAAACAGTAAATATTTGATTATTTTTCTTCAAATAA
AAGTATTGGATGGTGAATCATGAGTTCTAGTCCAGGTTCTGCCACAGTCTATTTGGGCAAGCTGCTCATA
CTCACTGACACCCCTCAACCCCTTTTTCTTAACTATAAAATAAGAAGGTTATTTTAGATCAATAAGTCTC
AAATTTGTTACACAAACGTGTCTTCTACAAAATGTTAATGTATGCCTTGTAATGAAAAGGATTTTGTGGT
CCAATAAATTCATGAACCATATCTTGGTCTTGTAGGTTCATAATACAGACATCTGTGGATCTGAGAAGTC
CTGCAGTGAGGAAATTTTTCCAATATTTTTCACCCTTAATTTGGCCATGGAATTTAATTCTTTCTTTTCT
TTTCTTTTTTCTTTTTTTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGG
AGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCCAACTCCCGGGTTCAAGCAATTCTTCTGCCTCAGC
CTCCCAAGCAGCTGGGACTACAGGTGCGTGCCACCATGTCCAGCTAATTTTTGTATTTTTAGTACAGACA
GGGTTTCACCATATTGGCAAAGCTGGTATTGAACTCCTGACCTCATGATCCGCCCACCTTGGCCTCTCAA
AGTGCTGCCATTACAAGCGTGAGCCACCGCACCCGGCCGGAATCTAATTCTTTCTATGAAAACTTTTACT
TATCTGGATCTCTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTTACCCAGGCTGGAGTGC
AGTGGCGTGATCTGGGGTCAATGCAACCTCAGCCTCCTGGGTTCAAGCGATTCTTGTCCTTCAGCCTCCC
AAGTAGCTGGGACTACAGGCATGTGCCACCACGCCCTAATAATTTTTTGTATTTTTAGTAGAGATGGGGT
TTCACCAAGTTGGTCAGGCTGGTTTCGAATTCCTGGCCTCAAGTGATCCACCCGCCTTGGCCTCCCAAAG
TTCTGGGATTACAAGAGTAAACCACCTTGCCTGGGCTTACTTAGCTGATCTCTTAAGTTTCTTTCCCATT
TTAATAATTTTTAAAATTATAAGTCATAAGTTAGAACATAGGGCTCCCTCTACAATTTTTAATATCAGTT
TTAGCTTCTAATACCTTTAAATCTGCTCTCAAGAGCACTCACACCTCCCCATAAAAGGTAACCCTTTAGA
CAAGGCATGGAGGGTCATGATAGATTTTGCTGGTAGCCATCACCCTCATTGCTCAAAGGACCAAGACAGG
TCTGGGGCTTGCTTGAGGCTGGGGTTGCTTAAATAAAGGGATCCCTTCCAAACTGAGACCCTTTTGGAAT
CCTCCTTTCTTTTAGAATCCTCCTCTCTGAAGGAAGAAGGTCATGCTTCCTTAGGCCCCCATAAGTTTTC
CAGTGGACTATAGCAGGGTTTTGTGCGGTCGAAACCAGGCTTTTCTTACTTGTGTATGGTTCATCAATTT
CTTTGAATGACTCTTTAGATGAGCACTTACAAGAGAAATAAATCATACATCTGCAAACTTTCTGAGGGCA
TCTCAGAGCTCATCTTGTCTAGGATGATGTCTTAGTCCCTTCCTGCTGCTGTAACAAAAAATACCTTGAC
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TGCGTAATTTATAAGAACAGAAATTTATTTCTCATAGTTCTGGAGGCTGGGAACTCCATGATCAAGGCAC
CAGGAGATTTAGGGTCTGGTGAGGGCTCACTCTCTGCTTCAAAGACGGTGCCTTCTCTGTGTCCTAACAT
GGCAGAAGGGCAAAAAAAGATCTAACAGACTCGCTCAAGCCCTTTTGCAAGGGCACAAATTCCATTCATG
AGTGTGGAGTCCTCATGATCTAATCACCTCCTAGACACCCCACTTCTTAATACTATTACACTGGGGATTA
AGCTACAACATAAATTTTGGAGGGACAGAAACATTCCAACCATAGCAGATGACAAATATATGCCCCATAC
TCAGTCATTATCCCTTCCTTCACTCTAGACAGGCACCACTAATCTATCATGGGAATCTTTCATGTAGAGT
GCAGACACGGCCACAGAATCCTTCTCAACACAGTTCCCCAGACAATCACACGCAATGAGCCAATCAGTAT
TGGTACATGTGTTGGAATCTGGTGGCCATCCTTAATCTAGTCTAAAGTCTCATTGTACAGAAAAGAAAAC
TGAGCCTCAGAGAAGTTAAATGATTTTCTTAAGATCATACAATCAGTTTAGCCCTGAAAAGAGTCAGAAA
TAAAACTATTTTGCCTATGGATGAAGCCAATTAGTAGAAAGAATTAATGTAGAACTTTCTGCCCCGCACT
AGCGCTGTAGTCAGAAGAGGCCTAAAGCCCAGATTTGTTCAGCTGTCTCTGGATTTTCTAGAGCCAAACT
CCTGCAAGATCAGAATCTACTGATAAATGTCAAACTCTTCCCCAAAGGATACCAAGCTAGGCCACTGACA
GATCCCACATCATTTTCTGTGATTTTCCAAAATAACTTTCAGGAGCAGTGCCCATGGCTGCACCCTTCTT
TCGATTTTTTTAAAGATTCCTTTTCCTTCTCTTCACTCCTGCCACCAGTGACCTAAAGCTCCAGAAAAGT
GACAAGTGGCATCTCCTTTCTTTGCAGGGGAAAGGCAAATTATTCTAGAGCAGGAAGCAGTTCAGACTTA
GAGCAAAACAATTACAGTAGAGCCATGGGCTACCCAGACCACAACGCTAGCCTTTGGTTATCTAAGATCT
TAGATAAACCAAATTTGAAGTCCTGGAATAGCTAACTTGTCCCCAGCTTGGGTTAAAAGCATAGAGATGC
TGGTAGGCCTGGCTTTGAATCCCCAACTCTGCCTTCTGCTACCAGAACAGCCTCTCTGAGCTTCAGTTTA
CTCATGTGGAAAAAGGATAATATTTATCTCTTAAGATTGTTGGGAAAATTAATGAGGTAAATTGAGAAAG
CACATAATAGATGCTCAGTAAACAGTAGTTTTCATTAGAATTATGATTAACTCATTTGTGTCAGGGAAAC
TAATGCTTTCTTTCTGCAAGAAGTAAGAGGAGAACACTCGGGCCATAGCTGTGTGTCCTGAACGTCTAGC
GCAGGCTAGATATGACATTAACAACTCAATTGTTGGCAACAAGGCCCCACGAGGCACAAAGGCACGGAAC
TTTAGGACACTGCTGCCATTGGGCTTTGGAGACCAGCCTTGCCTAATCAACCAAGGAGATCTCTTGTTTC
AGGCTGATTTGGGTGGAAGTTGTATGGCCCCAGCCCGCATGTTTACATGCTCCAAAAGAGGATGGCCACACAACTAATCTCTCCTTTGTCTTTTCCCAGGCACATCCACTGTAGTATGCAAGCCTATAGTCATTGAAACT
CAGCTCTATGTTATTGTGGCCCAGCTGTTTGGTGGCTCTCACATCTATAAGCGAGACAGTTTTGCAAATA
AATTCATAAAAATCCAGGATATTGAAATTCTCAAAATCCGAAAACCCAATGACATTGAAACATTCAAGAT
TGAAAACAACTGGTACTTTGTTGTTGCTGACAGTTCAAAAGCTGGTTTTACTACCATTTACAAATGGAAC
GGAAACGGATTCTACTCCCATCAATCCTTACACGCGTGGTACAGGGACACTGATGTGGAATATCTAGAAA
TAGTCAGAACACCTCAGACACTCAGAACGCCTCATTTAATTCTGTCTAGTAGTTCCCAGCGTCCTGTAAT
TTATCAGTGGAACAAAGCAACACAATTATTCACTAACCAAACTGACATTCCTAACATGGAGGATGTGTAC
GCAGTGAAGCACTTCTCAGTGAAAGGGGACGTGTACATTTGCTTGACAAGATTCATTGGTGATTCCAAAG
TCATGAAATGGGGAGGCTCCTCGTTCCAGGATATTCAGAGGATGCCATCGCGAGGATCCATGGTGTTCCA
GCCTCTTCAAATAAATAATTACCAATATGCAATTCTTGGAAGTGATTACTCCTTTACTCAAGTGTATAAC
TGGGATGCAGAGAAAGCCAAATTTGTGAAATTTCAGGAATTAAATGTTCAGGCACCAAGATCATTCACAC
ATGTGTCCATTAATAAGCGTAATTTTCTTTTTGCTTCCAGTTTTAAGGGAAATACACAGATTTACAAACA
TGTCATAGTTGACTTAAGCGCATGAGACACCAAATTCTGTGGCTGCCATCAGAAATTTTCTACAGTACAT
GACCCGGATGAACTCAATGCATGATGACTCTTCTTATCACACTTGCAAATGAATGCCTTTCAAACATTGA
GACTGCTAGAACCAAGCACTACCAGTATCTCCATCCTTAACTGTCCAGTCCAGTGATGTGGGAAGTTACCTTTTATAAGACAAAATTTAATTGTGTAACTGTTCTTTGCAGTGAAGATGTGTAAATAAGCGTTTAATGGT
ATCTGTTACTCCAAAAAGAAATATTAATATGTACTTTTCCATTTATTTATTCATGTGTACAGAAACAACT
GCCAAATAAAATGTTTACATTTTCTTTCATA
La secuencia del mRNA es la siguiente,
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>gi|171846229|ref|NM_005097.2| Homo sapiens leucine-rich, glioma inactivated 1 (LGI1), mRNA
GAAAGCAGAAAGCTGTTTATTTTCTGTGACATCACTTCACTTTGCCTTCGAAGGCTGGTCTGTGCTCAGT
GTTTTCGTGGTGATGCAAGTCGGCTCTCTCCTCCAGCAGTTGGATCCCTCCCATCTCACAGTACCTCACA
GGTCTCTTCCCCCGAGCAGTGCATTGCTGGAGCGAGGAGAAGCTCACGAATCAGCTGCAGGTCTCTGTTT
TGAAAAAGCAGAGATACAGAGGCAGAGGAAAAGGGTGGACTCCTATGTGACCTGTTCTTAGAGCAAGACA
ATCACCATCTGAATTCCAGAAGCCCTGTTCATGGTTGGGGATATTTTCTCGACTGCATGGAATCAGAAAG
AAGCAAAAGGATGGGAAATGCCTGCATTCCCCTGAAAAGAATTGCTTATTTCCTATGTCTCTTATCTGCG
CTTTTGCTGACTGAGGGGAAGAAACCAGCGAAGCCAAAATGCCCTGCCGTGTGTACTTGTACCAAAGATA
ATGCTTTATGTGAGAATGCCAGATCCATTCCACGCACCGTTCCTCCTGATGTTATCTCATTATCCTTTGT
GAGATCTGGTTTTACTGAAATCTCAGAAGGGAGTTTTTTATTCACGCCATCGCTGCAGCTCTTGTTATTC
ACATCGAACTCCTTTGATGTGATCAGTGATGATGCTTTTATTGGTCTTCCACATCTAGAGTATTTATTCA
TAGAAAACAACAACATCAAGTCAATTTCAAGACATACTTTCCGGGGACTAAAGTCATTAATTCACTTGAG
CCTTGCAAACAACAATCTCCAGACACTCCCAAAAGATATTTTCAAAGGCCTGGATTCTTTAACAAATGTG
GACCTGAGGGGTAATTCATTTAATTGTGACTGTAAACTGAAATGGCTAGTGGAATGGCTTGGCCACACCA
ATGCAACTGTTGAAGACATCTACTGCGAAGGCCCCCCAGAATACAAGAAGCGCAAAATCAATAGTCTCTC
CTCGAAGGATTTCGATTGCATCATTACAGAATTTGCAAAGTCTCAAGACCTGCCTTATCAATCATTGTCC
ATAGACACTTTTTCTTATTTGAATGATGAGTATGTAGTCATCGCTCAGCCTTTTACTGGAAAATGCATTT
TCCTTGAATGGGACCATGTGGAAAAGACCTTCCGGAATTATGACAACATTACAGGCACATCCACTGTAGT
ATGCAAGCCTATAGTCATTGAAACTCAGCTCTATGTTATTGTGGCCCAGCTGTTTGGTGGCTCTCACATC
TATAAGCGAGACAGTTTTGCAAATAAATTCATAAAAATCCAGGATATTGAAATTCTCAAAATCCGAAAAC
CCAATGACATTGAAACATTCAAGATTGAAAACAACTGGTACTTTGTTGTTGCTGACAGTTCAAAAGCTGG
TTTTACTACCATTTACAAATGGAACGGAAACGGATTCTACTCCCATCAATCCTTACACGCGTGGTACAGG
GACACTGATGTGGAATATCTAGAAATAGTCAGAACACCTCAGACACTCAGAACGCCTCATTTAATTCTGT
CTAGTAGTTCCCAGCGTCCTGTAATTTATCAGTGGAACAAAGCAACACAATTATTCACTAACCAAACTGACATTCCTAACATGGAGGATGTGTACGCAGTGAAGCACTTCTCAGTGAAAGGGGACGTGTACATTTGCTTG
ACAAGATTCATTGGTGATTCCAAAGTCATGAAATGGGGAGGCTCCTCGTTCCAGGATATTCAGAGGATGC
CATCGCGAGGATCCATGGTGTTCCAGCCTCTTCAAATAAATAATTACCAATATGCAATTCTTGGAAGTGA
TTACTCCTTTACTCAAGTGTATAACTGGGATGCAGAGAAAGCCAAATTTGTGAAATTTCAGGAATTAAAT
GTTCAGGCACCAAGATCATTCACACATGTGTCCATTAATAAGCGTAATTTTCTTTTTGCTTCCAGTTTTA
AGGGAAATACACAGATTTACAAACATGTCATAGTTGACTTAAGCGCATGAGACACCAAATTCTGTGGCTG
CCATCAGAAATTTTCTACAGTACATGACCCGGATGAACTCAATGCATGATGACTCTTCTTATCACACTTG
CAAATGAATGCCTTTCAAACATTGAGACTGCTAGAACCAAGCACTACCAGTATCTCCATCCTTAACTGTC
CAGTCCAGTGATGTGGGAAGTTACCTTTTATAAGACAAAATTTAATTGTGTAACTGTTCTTTGCAGTGAA
GATGTGTAAATAAGCGTTTAATGGTATCTGTTACTCCAAAAAGAAATATTAATATGTACTTTTCCATTTA
TTTATTCATGTGTACAGAAACAACTGCCAAATAAAATGTTTACATTTTCTTTCATA
La siguiente informacin presenta la regin correspondiente al exn, la secuencia
codigicante (CDS) y la protena traducida.
Mediante la herramienta clustalw se realiza un alineamiento entre la secuencia total del
gen y la secuencia del ARNm.
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Los resultados muestran un score de 100 entre la secuencia A (ADN) y la secuencia B
(mRNA) , lo cual confirma que el mARN de 2366 pb es la transcripcin del gen ILGI1 de
47351 pb.
El alineamiento en detalle se presenta a continuacin,
CLUSTAL 2.1 multiple sequence alignment
EpilpesyDNA TTCTAAAGTTCATGAATGTTTGCACTTGAGAAACCTTATATTTAATTAGTGGAGGTAGAA36000EiplepsymRNA ---------------------------------------------------------GAA 3
***
EpilpesyDNA GACATAGACTTTTGAGAATGTTTTAAAGGGAAGTTGAGAGAATTTTCAAGGGTTTAGAGG36060EiplepsymRNA AGCA------------------------GAAAGCTG------------------------ 15
** * *** **
EpilpesyDNA CTAATGGTATGGGCTCTTTAGTTTTAGTTTAGTTTTTTATTTTTATTGTGGAAAAAAAAA36120EiplepsymRNA -----------------------------------TTTATTTT--CTGTG---------- 28
******** ****
EpilpesyDNA ACACCTCTAAGAAAAGTTTATAACGTGTATATATATGGTGCTGGTTAAAAATAGAAAATT36180EiplepsymRNA ------------------------------------------------------------
EpilpesyDNA ACACTACTTGGTGACCTTCCCCAGTCATACAGCATTAGCACTGTGCTATGTCTATATTTG36240EiplepsymRNA ACATCACTT-----------------------------CACTTTGC-------------- 45
*** **** **** ***
EpilpesyDNA TGTACTAGGGACACATTTCCCTTTCCTTGACATTATCAGGACAATTTTTTACTCATTAAC36300EiplepsymRNA ------------------------CTTCGA-------AGG-------------------- 54
* * ** ***
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EpilpesyDNA CTTTATTAGAATCATTCTAGTGATTTACGGAAGAACAAATAGAAAGGGAAAGGGAAAAAC36360EiplepsymRNA ----------------CTGGT--------------------------------------- 59
** **
EpilpesyDNA ATTCCTGTGATCACAGGAAAAGAACCAGAAGAAGGAGAAAGAGGGGGATGATTAAAGAGA36420EiplepsymRNA ----CTGTGCTCA----------------------------------GTG---------- 71
***** *** **
EpilpesyDNA ATAGATGGATAGGTTTTTATAAGAAAACTTTTTTCTGAGGTGGAATGAATGGTGCTAGAA36480EiplepsymRNA ------------------------------TTTTC----GTGG------TGATGCAAG-- 89
***** **** ** *** **
EpilpesyDNA AGGAAAAGGAGGCGTGGGCTTTAGAAAGGAGAAAGGATGTACTGGGGAAGAGATAGAGCT36540EiplepsymRNA --------------TCGGCT---------------------------------------- 95
* ****
EpilpesyDNA ACTGGCACTGTGGGTTGGAGGTTTGGTTGCTCTCCGGAGCAAGCGAGGAGGAAGCAGGCA36600EiplepsymRNA -----------------------------CTCTCC-------------------------101
******
EpilpesyDNA GAAGGGGCAGCCCAGGCAAGAGGAGGGGGCGCATTTTGGAGATGGACACTCACCAGTTTG36660EiplepsymRNA ----------TCCAG--------------------------------------CAGTT--111
**** *****
EpilpesyDNA GTTAGTCATCATTTGGGAGATATCCCCTAGATTGAGCGTCTGAGAGTGTGAATCTCTCGT36720EiplepsymRNA -----------------GGATCCCTCCCA---------TCTCACAGT----ACCTCACAG141
*** * ** * *** * *** * *** *
EpilpesyDNA GTTCTGTTCTAAATGGAAAGATCAATGCCCAGGAATCATTGTTGTTTTTAACCAACATAA36780EiplepsymRNA GT-CTCTTCC-----------------CCCGAGCA-------------------------158
** ** *** *** * *
EpilpesyDNA AGTGTTGTTTAAATATTGAGTGCACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGT36840EiplepsymRNA -------------------GTGCATT----------------------GCTGGAGCGAG-176
***** ** * *** *
EpilpesyDNA GGATCACTGAAGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCT36900EiplepsymRNA -GA-----GAAGCTCACGAAT---------------------------------------191
** ******** ** *
EpilpesyDNA ACTAAAAATACAACAATTAGCCGGGTATGGTGGCGGGCACATGTAATCCCAGCTACGGCA36960EiplepsymRNA -------------------------------------------------CAGCTGC----198
***** *
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EpilpesyDNA GGCTAAGGCAGGAAAATCACTTGAACCCGGGAGGCAGAGGTTTCAGTGAGCTGAGGTCAC37020EiplepsymRNA -------------------------------------AGGTCTC----------------205
**** **
EpilpesyDNA ACCACTTCACTCCAGCCTGGGTGACAGAGCGAGACTTTTGTCTCAAGAAATAAAAGTAAA37080EiplepsymRNA --------------------------------------TGTTTTGA-----AAAAGCAG-221
*** * * ***** *
EpilpesyDNA TAAATATGGAGTGGGTGTTGAAGTGAACAGGTTAGGAACTGAAAGGACAATAGCAGGAAT37140EiplepsymRNA -AGATACAGAG-----------------------------------------GCAG----235
* *** *** ****
EpilpesyDNA CTGAGTAGTAGTTCAGAAGAAAAAAAAAGGACCACAAGTCTTTTAGTAGGCTGGAAATGA37200EiplepsymRNA ---------------------AGGAAAAGG---------------GTGGACT--------251
* ****** ** * **
EpilpesyDNA CAAAAGAGACTCATCACTAAGCTTTATCATTAAATGCCTTTGTTTAATTTATCACTACAG37260EiplepsymRNA ------------------------------------CCTATGT-----------------258
*** ***
EpilpesyDNA TTTACATCACCTTTTTTTTTTTTTTTCCAGGAGCCTTGCAAACAACAATCTCCAGACACT37320EiplepsymRNA ------------------------------------------------------------
EpilpesyDNA CCCAAAAGATATTTTCAAAGGCCTGGATTCTTTAACAAATGTGTAAGAGGACCTAAGAAA37380EiplepsymRNA -------------------GACCTG--TTCTT-------------AGAG----CAAGA--278
* **** ***** **** ****
EpilpesyDNA TCACTGAACAATTAATTAATTTGCAGTCATTAACAAGGAAGCCTGGTATTGATTATTATA37440EiplepsymRNA -----------------------CAATCACCA----------------------------287
** *** *
EpilpesyDNA ATTTTTAATTGGCTTTTAAATTAAAATTAGGATTTTTAAATCTAAATTTTAACTGGCCAA37500EiplepsymRNA ----------------------------------------TCTGAATT--------CCAG299
*** **** ***
EpilpesyDNA AAATTTAAATTTACATGGACTAACATTTGAGTCTTCTATGGTATTTATCATTGGGAATTC37560EiplepsymRNA AAGCCC-----------------------------------TGTTCATGGTTGGGGAT--322
** * ** ** ***** **
EpilpesyDNA TGAATACATGGCACCCAGGCATTCCTTTGACAAAGTGTGTGTCAATACGGCAGGGAGCGA37620EiplepsymRNA --------------------ATTTTCTCGAC----TGCATG-------------------339
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*** * *** ** **
EpilpesyDNA TGATAAAGGACTTTGACGGGGTGGGAAGAGACCCGGCTAGAAATTTCAAAATCCCTTTTT37680EiplepsymRNA ---------------------------------------GAA---TCAGAA---------348
*** *** **
EpilpesyDNA TCTCATGAGGTCCAGGAAATAGGGCTACAAAGGAAAAACATAAAGGAGTCTGGGAAACTG37740EiplepsymRNA ---------------------------------AGAAGCA-AAAGGA---TGGGAAA---368
* ** ** ****** *******
EpilpesyDNA ACAGAATAAAGATGAAAGGTTACATCCTTGGGTTGGTCAATCAACAGAGAAATGGAACAG37800EiplepsymRNA ------------------------------------------------------------
EpilpesyDNA GAAGTGGGGGAAGGGAGAAAAGTTTGCCTTTTTTCTCATTAGACTGAACAACAACTCTAA37860EiplepsymRNA ------------------------TGCCTGCATTCCC------CTGAA-AAGAATT----393
***** *** * ***** ** ** *
EpilpesyDNA GCTTAATCCCCAGGAATTTGGCTTAAGCCCCAGGAAGGGAATGAACTTAATTATTTTTGA37920EiplepsymRNA GCTTATTTCCTA------TGTCTC--------------------------TTATCT----417
***** * ** * ** ** **** *
EpilpesyDNA CCCTTTTTCAAACAAAAGAGCTTTCAAACTTTGACTTTTAAGCCTCCGAGTGAAAGATCT37980EiplepsymRNA -----------------GCGCTTTTG----CTGACT-----------GAGGGGAAGA---442
* ***** ***** *** * ****
EpilpesyDNA TTGCAAGGAATTTGTATATTTTGCTGTAAGCAAAGCAAGTAATATATGCCTAAACTTCTC38040EiplepsymRNA --------AACC----------------AGCGAAGC-----------------------C455
** *** **** *
EpilpesyDNA AAAAGCAATTCAGCTTCATTATTTGCCTTCCAGAACATTAGAAAGGTATTTAAATGTCAT38100EiplepsymRNA AAAA-------------------TGCCCTGCCG---------------------TGT---472
**** **** * * * ***
EpilpesyDNA AAGGTGGAAGACAGGAACAAATGAAAGGATATATGAAAACAAAAGCTTTTTTAAAAAATT38160EiplepsymRNA ------------------------------------------------------------
EpilpesyDNA ATTCAGGTACTTGTCTGTAGAATATATATTCAAAACAACTTTTCTCCAATAACAAACAAA38220EiplepsymRNA ------GTACTTGT----------------------------------------ACCAAA486
******** * ****
EpilpesyDNA AAGAAAATCTGAGTCAAGTACTTTCTTCCAAGCCCAGTATTTAACTTCAAATCAGTAGCC38280
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EiplepsymRNA GA----------------------------------------------------------488
*
EpilpesyDNA TAATGAAAAACTTTCTTTGTTCCTTGCAGTATTTCCCCAGCCCCTCCTCCATGTCTATTA38340EiplepsymRNA TAATG-----------------------------------------CTTTATGT------501
***** ** ****
EpilpesyDNA CCTCAATTCCTGAATGATATGGTTTAATTCCAGGAGAATGCCCAAATCAGGATTCTTCCA38400EiplepsymRNA ---------------------------------GAGAATGCCAGATCCA------TTCCA522
********* * ** *****
EpilpesyDNA AGAGAGTCCTGGACAGACCATAGTTATCCTCTCTGGTTTACAGTAGCCTGAAAGGTTGCC38460EiplepsymRNA -------------CGCACCGT-----TCCTC-CTGAT-----------------GTTATC546
* *** * ***** *** * *** *
EpilpesyDNA ACTCATTAGTGTGGGTCAGAGTTCTCTTGGGAGACTAGGTCAGTTCTGGGAGTGTCTTGG38520EiplepsymRNA --TCATTA--------------TCCTTTGTGAGA----------TCTGG-----------569
****** ** *** **** *****
EpilpesyDNA AAGTTAGAACACACTCCATGGGTGACGTGGGATGTAGCTCATTGGGGGTCCTTTACCCCA38580EiplepsymRNA --------------------------------------------------TTTTAC----575
*****
EpilpesyDNA TTTTTGTGTCAGTCTATACCCTACACTAGTGAAAGACAAAACAAAAAAATATTGAAATTG38640EiplepsymRNA ----------------------------------------------------TGAAAT--581
******
EpilpesyDNA GCTCAGTCTCTCATGGGAATCCCAAGATGGGTTTAGCCTTTTGGACCTACTCTAATATGC38700EiplepsymRNA -CTCAG------AAGGGAGTT-----------------TTTT------------------599
***** * **** * ****
EpilpesyDNA CCAAATCAAGAATTATCTTAGAAGTACAAGGATCCATGCCAACTTGCCTTTTAGTGGATT38760EiplepsymRNA -------------------------------ATTCACGCCA--TCGC-------TGCAGC619
** ** **** * ** ** *
EpilpesyDNA TCTTGGCTTTCTTGAAAGTATCCTCTAAAAAACATTTTTAAATGTTTGGGCGTTTAAAAA38820EiplepsymRNA TCTTG-------------------------------------------------------624
*****
EpilpesyDNA TTATTTATGTGTGGTGTGAAGAGTAGGCAGCACCTATCTTAAGAATTCTGTGTGACCAGG38880EiplepsymRNA TTATTCAC---------------------------ATC----------------------635
***** * ***
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EpilpesyDNA AAAGGAGGTGGAATTCCTGAACAGAAGCAATGCAAATACACAGAGAACTTGGTGAGTTGG38940EiplepsymRNA ----------GAACTCCT------------------------------TTGATG------649
*** **** *** **
EpilpesyDNA GGTCATATGTGGATATGTAAATGGTCTATGCTGTATAACTTATTACAGGCATGAGCGATT39000EiplepsymRNA ---------------------TGATCAGTG--------------------ATGA------662
** ** ** ****
EpilpesyDNA GTATGCCTGTGTTAACTCTGCTGTGTCAAAGTCATTTCCTATTTAAACTGAATTTGTAGA39060EiplepsymRNA ------------------TGCT-------------------TTTA--------TTG----673
**** **** ***
EpilpesyDNA CCACGGAAGAGGATCAGGATTAATTATGTCTGTGAGGAAGAAGAAAAGCAAATAGCTCAC39120EiplepsymRNA ---------------------------GTCT-----------------------------677
****
EpilpesyDNA TTGATTAAATACATTACAATAATCACTACATTCTGTCCTTTAGACCTGTGCTGTCCAATA39180EiplepsymRNA -----------------------------------------------------TCCA---681
****
EpilpesyDNA GGGTAGCCACCAGACCTTATGGTCACTGAGCACCTAAAATGTGCTCCTAGTACAACTGAG39240EiplepsymRNA ------------------------------CATCTAGAGT--------------------691
** *** * *
EpilpesyDNA AGACTGAATTTTAAATTTTACTTAATTTTTTAACAGTTAAATTTAAATTTAAAAGCTGAT39300EiplepsymRNA ------------------------ATTTATTCATAG--------------AAAA------707
**** ** * ** ****
EpilpesyDNA TCTCAGCTCAATTATTGGAAAATGTTAAGTACGCTTGGAATAATTTGGGTATATACACCT39360EiplepsymRNA ---CAAC-------------AACATCAAGTC-----------------------------722
** * ** * ****
EpilpesyDNA ATTTTTTTCAATTATGAATTTTATGACATCTAAATATAGATCACCTATTTCTGGTAAAAT39420EiplepsymRNA ----------------AATTTCAAGACAT-------------AC---TTTCCGG------744
***** * ***** ** **** **
EpilpesyDNA TTAGCATCTGAATTGAGATATATTGTAGGTATAAAATACACACTGGACTTCAAAGACTTA39480EiplepsymRNA --------------------------------------------GGACT-----------749
*****
EpilpesyDNA GTATAAAAAAGGAATGTAAAATATCTCAATAATGTTTATATTGATGATGTGTCAAAATGA39540
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EiplepsymRNA -------AAAG-------------------------------------------------753
****
EpilpesyDNA TAATCTTTTGTATGTATTGGGTTAAATAAAACATATTATTAAAATGAATTATACCTGCTT39600EiplepsymRNA -----------------------------------TCATTAA------------------760
* *****
EpilpesyDNA CTTTTTACTTTTTTAATGTGGCTATAGAAAATTTTAAATTACAATTACGGTTCATATACT39660EiplepsymRNA ---TTCACTT----------------GAGCCTTGCAAACAACAATC----TCCAGACACT797
** **** ** ** *** ***** * ** * ***
EpilpesyDNA GTTTCTATTGACAGCACAGCCCTAGACTAAGCCGCTTTGGAATTCAAGAGGGAGTAAGTG39720EiplepsymRNA ------------------------------------------CCCAAAAGATA-------808
*** ** *
EpilpesyDNA ATGAGGTTCCATTGACTGGGTAGTCTTCAAGTGTGCATGGTGCTAACTCTCTGAGCCCAA39780EiplepsymRNA -----------------------TTTTCAA------------------------------815
* *****
EpilpesyDNA AGTGAATGAGTGGTCAGTCAGGTTCCAGGCAGGTTATAGGGCAGGATGCAACGCCGGGTA39840EiplepsymRNA -------------------------------------AGGCCTGGAT-------------825
*** * ****
EpilpesyDNA AGGTCATTCTGCACATGTTAATTGTTGATGTAGAACTCTTTCCTGCGTGGGTAGGGCCCT39900EiplepsymRNA ------------------------------------TCTTT-------------------830
*****
EpilpesyDNA TGTACAGCAAAAGCAGCTGAAGTTTGTCTTTCAGGGACCTGAGGGGTAATTCATTTAATT39960EiplepsymRNA -----AACAAA-------------TGT-------GGACCTGAGGGGTAATTCATTTAATT865
* **** *** **************************
EpilpesyDNA GTGACTGTAAACTGAAATGGCTAGTGGAATGGCTTGGCCACACCAATGCAACTGTTGAAG40020EiplepsymRNA GTGACTGTAAACTGAAATGGCTAGTGGAATGGCTTGGCCACACCAATGCAACTGTTGAAG925
************************************************************
EpilpesyDNA ACATCTACTGCGAAGGCCCCCCAGAATACAAGAAGCGCAAAATCAATAGTCTCTCCTCGA40080EiplepsymRNA ACATCTACTGCGAAGGCCCCCCAGAATACAAGAAGCGCAAAATCAATAGTCTCTCCTCGA985
************************************************************
EpilpesyDNA AGGATTTCGATTGCATCATTACAGGTAATGTACTCATCATCATTCCACCTCAAAAAATTA40140EiplepsymRNA AGGATTTCGATTGCATCATTACAG------------------------------------1009
************************
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EpilpesyDNA TCTAGCCAAGGAAAGAGGTATTAGCTCACAGTTACTTATTATTTCCTATTTTTGCAGAAT40380EiplepsymRNA ---------------------------------------------------------AAT1012
***
EpilpesyDNA TTGCAAAGTCTCAAGACCTGCCTTATCAATCATTGTCCATAGACACTTTTTCTTATTTGA40440EiplepsymRNA TTGCAAAGTCTCAAGACCTGCCTTATCAATCATTGTCCATAGACACTTTTTCTTATTTGA1072
************************************************************
EpilpesyDNA ATGATGAGTATGTAGTCATCGCTCAGCCTTTTACTGGAAAATGCATTTTCCTTGAATGGG40500EiplepsymRNA ATGATGAGTATGTAGTCATCGCTCAGCCTTTTACTGGAAAATGCATTTTCCTTGAATGGG1132
************************************************************
EpilpesyDNA ACCATGTGGAAAAGACCTTCCGGAATTATGACAACATTACAGGTATGAAAAGCCTAATGA40560EiplepsymRNA ACCATGTGGAAAAGACCTTCCGGAATTATGACAACATTACAGG-----------------1175
*******************************************
EpilpesyDNA TATTTTGAGTGGTAATTTAAACTGCTTCAGCCAAGGGCAACAAGGAAAGATGAGTGGTAT40620EiplepsymRNA ------------------------------------------------------------
EpilpesyDNA CACATCCACTGTAGTATGCAAGCCTATAGTCATTGAAACTCAGCTCTATGTTATTGTGGC44220EiplepsymRNA CACATCCACTGTAGTATGCAAGCCTATAGTCATTGAAACTCAGCTCTATGTTATTGTGGC1235
************************************************************
EpilpesyDNA CCAGCTGTTTGGTGGCTCTCACATCTATAAGCGAGACAGTTTTGCAAATAAATTCATAAA44280EiplepsymRNA CCAGCTGTTTGGTGGCTCTCACATCTATAAGCGAGACAGTTTTGCAAATAAATTCATAAA1295
************************************************************
EpilpesyDNA AATCCAGGATATTGAAATTCTCAAAATCCGAAAACCCAATGACATTGAAACATTCAAGAT44340EiplepsymRNA AATCCAGGATATTGAAATTCTCAAAATCCGAAAACCCAATGACATTGAAACATTCAAGAT1355
************************************************************
EpilpesyDNA TGAAAACAACTGGTACTTTGTTGTTGCTGACAGTTCAAAAGCTGGTTTTACTACCATTTA44400EiplepsymRNA TGAAAACAACTGGTACTTTGTTGTTGCTGACAGTTCAAAAGCTGGTTTTACTACCATTTA1415
************************************************************
EpilpesyDNA CAAATGGAACGGAAACGGATTCTACTCCCATCAATCCTTACACGCGTGGTACAGGGACAC44460EiplepsymRNA CAAATGGAACGGAAACGGATTCTACTCCCATCAATCCTTACACGCGTGGTACAGGGACAC1475
************************************************************
EpilpesyDNA TGATGTGGAATATCTAGAAATAGTCAGAACACCTCAGACACTCAGAACGCCTCATTTAAT44520EiplepsymRNA TGATGTGGAATATCTAGAAATAGTCAGAACACCTCAGACACTCAGAACGCCTCATTTAAT1535
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************************************************************
EpilpesyDNA TCTGTCTAGTAGTTCCCAGCGTCCTGTAATTTATCAGTGGAACAAAGCAACACAATTATT44580EiplepsymRNA TCTGTCTAGTAGTTCCCAGCGTCCTGTAATTTATCAGTGGAACAAAGCAACACAATTATT1595
************************************************************
EpilpesyDNA CACTAACCAAACTGACATTCCTAACATGGAGGATGTGTACGCAGTGAAGCACTTCTCAGT44640EiplepsymRNA CACTAACCAAACTGACATTCCTAACATGGAGGATGTGTACGCAGTGAAGCACTTCTCAGT1655
************************************************************
EpilpesyDNA GAAAGGGGACGTGTACATTTGCTTGACAAGATTCATTGGTGATTCCAAAGTCATGAAATG44700EiplepsymRNA GAAAGGGGACGTGTACATTTGCTTGACAAGATTCATTGGTGATTCCAAAGTCATGAAATG1715
************************************************************
EpilpesyDNA GGGAGGCTCCTCGTTCCAGGATATTCAGAGGATGCCATCGCGAGGATCCATGGTGTTCCA44760EiplepsymRNA GGGAGGCTCCTCGTTCCAGGATATTCAGAGGATGCCATCGCGAGGATCCATGGTGTTCCA1775
************************************************************
EpilpesyDNA GCCTCTTCAAATAAATAATTACCAATATGCAATTCTTGGAAGTGATTACTCCTTTACTCA44820EiplepsymRNA GCCTCTTCAAATAAATAATTACCAATATGCAATTCTTGGAAGTGATTACTCCTTTACTCA1835
************************************************************
EpilpesyDNA AGTGTATAACTGGGATGCAGAGAAAGCCAAATTTGTGAAATTTCAGGAATTAAATGTTCA44880EiplepsymRNA AGTGTATAACTGGGATGCAGAGAAAGCCAAATTTGTGAAATTTCAGGAATTAAATGTTCA1895
************************************************************
EpilpesyDNA GGCACCAAGATCATTCACACATGTGTCCATTAATAAGCGTAATTTTCTTTTTGCTTCCAG44940EiplepsymRNA GGCACCAAGATCATTCACACATGTGTCCATTAATAAGCGTAATTTTCTTTTTGCTTCCAG1955
************************************************************
EpilpesyDNA TTTTAAGGGAAATACACAGATTTACAAACATGTCATAGTTGACTTAAGCGCATGAGACAC45000EiplepsymRNA TTTTAAGGGAAATACACAGATTTACAAACATGTCATAGTTGACTTAAGCGCATGAGACAC2015
************************************************************
EpilpesyDNA CAAATTCTGTGGCTGCCATCAGAAATTTTCTACAGTACATGACCCGGATGAACTCAATGC45060EiplepsymRNA CAAATTCTGTGGCTGCCATCAGAAATTTTCTACAGTACATGACCCGGATGAACTCAATGC2075
************************************************************
EpilpesyDNA ATGATGACTCTTCTTATCACACTTGCAAATGAATGCCTTTCAAACATTGAGACTGCTAGA45120EiplepsymRNA ATGATGACTCTTCTTATCACACTTGCAAATGAATGCCTTTCAAACATTGAGACTGCTAGA2135
************************************************************
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EpilpesyDNA ACCAAGCACTACCAGTATCTCCATCCTTAACTGTCCAGTCCAGTGATGTGGGAAGTTACC45180EiplepsymRNA ACCAAGCACTACCAGTATCTCCATCCTTAACTGTCCAGTCCAGTGATGTGGGAAGTTACC2195
************************************************************
EpilpesyDNA TTTTATAAGACAAAATTTAATTGTGTAACTGTTCTTTGCAGTGAAGATGTGTAAATAAGC45240EiplepsymRNA TTTTATAAGACAAAATTTAATTGTGTAACTGTTCTTTGCAGTGAAGATGTGTAAATAAGC2255
************************************************************
EpilpesyDNA GTTTAATGGTATCTGTTACTCCAAAAAGAAATATTAATATGTACTTTTCCATTTATTTAT45300EiplepsymRNA GTTTAATGGTATCTGTTACTCCAAAAAGAAATATTAATATGTACTTTTCCATTTATTTAT2315
************************************************************
EpilpesyDNA TCATGTGTACAGAAACAACTGCCAAATAAAATGTTTACATTTTCTTTCATATCCCAGAGG45360EiplepsymRNA TCATGTGTACAGAAACAACTGCCAAATAAAATGTTTACATTTTCTTTCATA---------2366
***************************************************
EpilpesyDNA TAATTATTTACAGGAGCTGTTTCATTCTTGTTGTTGGTATGTTGAAGAAATAGTTTTATA45420EiplepsymRNA ------------------------------------------------------------
Con la herramienta expasy toolse realiza una prediccin de la transcripcin con base al mRNA,
debido a la naturaleza de cdigo gentico degenerado se presentan 6 frames, el frame elegido es
aquel con menor nmero de stop codons.
La secuencia de aminocidos es corrida en Blastprotein con el fin de identificar a que
protena pertenece.
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La protena con mxima identidad es NP_005088 Leucine-rich glioma-inactivated protein 1
coincidiendo con lo reportado en ncbi para el gen ILGI1.
Seguidamente se realiza un traduccin reversa partiendo de la proteina NP_005088 .1, se
obtienen dos posible secuencias.
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En la herramienta clustalw se realiza un alineamiento entre las dos secuencias obtenidas
en la traduccin reversa y la secuencia de mRNA correspondiente a LGI1.
Entre la secuencia Reversa1 y la secuencia mRNA se logra el mayor score de alineamiento(74.0), seguidamente se corre en Blast-nucleotide la secuencia Reversa1 y se aprecia que
evidentemente coincide con la secuencia del ARN mensajero del gen LGI1.
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Con la herramienta expasy-tool calculamos el punto isoelctrico y el peso molecular de la
protena.
Con la herramienta REBsites identificamos las enzimas de restriccin que menor nmero
de fragmentos produce en la secuencia de DNA del gen LGI1
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Para el diseo de primers se tiene en cuenta la regin del mRNA correspondiente a la
secuencia codificante (CDS) que comprende las regiones entre los nucletidos 337 y 2010.
Los primers con mayor porcentaje de GC, es decir los ms estables son mostrados en la
siguiente imagen.
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Referencias
[1] Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels. Smith SE,
Xu L, Kasten MR, Anderson MP. J Neurochem. 2012 Feb;120(4):611-21. doi:
10.1111/j.1471-4159.2011.07605.x.
[2] Familial temporal lobe epilepsy with psychic auras associated with a novel LGI1
mutation.Striano P, Busolin G, Santulli L, Leonardi E, Coppola A, Vitiello L, Rigon L,
Michelucci R, Tosatto SC, Striano S, Nobile C. Neurology. 2011 Mar 29;76(13):1173-6.
[3] Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated
1-deficient mice. Chabrol E, Navarro V, Provenzano G, Cohen I, Dinocourt C, Rivaud-
Pchoux S, Fricker D, Baulac M, Miles R, Leguern E, Baulac S. Brain. 2010 Sep;133(9):2749-
62. Epub 2010 Jul 21.
[4] The leading edge of epilepsy research. Ikeda A. Rinsho Shinkeigaku. 2011
Nov;51(11):993-6.
[5] Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate
synapses.Zhou YD, Zhang D, Ozkaynak E, Wang X, Kasper EM, Leguern E, Baulac S,
Anderson MP. J Neurosci. 2012 Jan 18;32(3):903-10.
[6] Low penetrance and effect on protein secretion of LGI1 mutations causing autosomal
dominant lateral temporal epilepsy. Di Bonaventura C, Operto FF, Busolin G, Egeo G,
D'Aniello A, Vitello L, Smaniotto G, Furlan S, Diani E, Michelucci R, Giallonardo AT, Coppola
G, Nobile C. Epilepsia. 2011 Jul;52(7):1258-64. doi: 10.1111/j.1528-1167.2011.03071.x.
Epub 2011 Apr 19.
[7] Autoimmune epilepsies. Irani SR, Bien CG, Lang B. Curr Opin Neurol. 2011
Apr;24(2):146-53. Review.
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[8] The temporal and spatial expression pattern of the LGI1 epilepsy predisposition gene
during mouse embryonic cranial development. Silva J, Wang G, Cowell JK. BMC Neurosci.
2011 May 13;12:43.
[9] LGI2 truncation causes a remitting focal epilepsy in dogs. Seppl EH, Jokinen TS,
Fukata M, Fukata Y, Webster MT, Karlsson EK, Kilpinen SK, Steffen F, Dietschi E, Leeb T,
Eklund R, Zhao X, Rilstone JJ, Lindblad-Toh K, Minassian BA, Lohi H.PLoS Genet. 2011
Jul;7(7):e1002194. Epub 2011 Jul 28.
[10] Similarity of molecular phenotype between known epilepsy gene LGI1 and disease
candidate gene LGI2. Limviphuvadh V, Chua LL, Rahim RA, Eisenhaber F, Maurer-Stroh S,
Adhikari S. BMC Biochem. 2010 Sep 24;11:39.