7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
1/30
Naghvf (Jgrocgaotrgpohf ) nh pfjonhtns
jgh Bflf Rnsnrvf/Rnspunstf Gvrojf
B. Jgrganu,K. avfrnz, K. Mnvnsf,R. Buxfmnrfs, K. Bgfmf y PH. Bfrro.
Znrvojog mn Knmojohf mn af Rnprgmujjoh.Mnpfrtfknhtg mn Gbstntrojof, Eohnjgagef y Rnprgmujjoh.
Ohstotut ^hovnrsotfro Mnxnus.
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
2/30
Bflf Rnspunstf nh COS / Ohtrgmujjoh
Ohjomnhjof)
Fsgjofmg) Nhmgkntrogsos(Bfrro y jga. 200>) OKJ nanvfmg (Rfheo y jga,. 2000)
Cfaag gvrojg gjuatg(Hfvgt y jga., 6?45) Bflf Rnsnrvf Gvrojf (Mnvnsf y jga. 2060) Ohnxpaojfmg (Infy y jga., 6??5)
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
3/30
Mncohojoh mn Rnspunstf Gvrojf Pgbrn(Pggr Rnspghsn, tdn Bgagehf jrotnrof)
Fa knhgs 2 mn ags soeuonhtns : fspnjtgs tonhnh qun nstfr prnsnhtns-5 cgajuags g FKD 10.>-6.6 he/ka)
Jghsomnrfjoghns/Fjafrfjoghns< Mgs nposgmogs mn Rnspunstf Gvrojf Pgbrn sgh sucojonhtns pfrf mncohor f
af pfjonhtn jgkg RGP nh fusnhjof mn nmfm kftnrhf fvfhzfmf g prunbfsmn Rnsnrvf Gvrojf fatnrfmfs. Na tnrkohg mn RGP sn rnconrn f rnspunstf, pgr ag qun af prnsnhjof mn uh
jojag mn nstokuafjoh ns nsnhjofa pfrf af mncohojoh. Zoh nkbfreg kulnrnsjgh nmfm fvfhzfmf jgh prunbf mn Rnsnrvf Gvrojf fatnrfmf punmn snrjghsomnrfmfs jgkg pgbrns rnspghmnmgrfs, fuhqun nh so sgh pgsobanspgbrns rnspghmnmgrfs.
Cnrrfrntto FP. nt fa. Duk Rnprgm, 2066Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
4/30
BflfRnspunstf
1 = gvgjotgs
HgrkgRnspunstf
DpnrRnspunstf
8 6> gvgjotgs
p
Hknrg 20: >42 54
Nmfm :?.6:.4 :3.?=.0 :>.?=.6 0.006
RCF 3.0=.5 60.0>.4 6>.45.3 0.006
CZD 60.3=.? 4.6:.2 5.02.6 0.006
FKD 0.56.= 6.32.6 2.?2.2 0.006
Fhtfeghostfs EhRD 5?.=% 4=.?% 4:.3% HZ
Gvgjotgs rnjupnrfmgs 2.60.? 4.2:.2 64.?2.4 0.006
Gvgjotgs KOO 6.:6.6 3.>2.4 66.?3.= 0.006
Gvgjotgs Ohsnkohfmgs 6.=6.6 3.4:.0 62.?5.0 0.006
Gvgjotgs Cnjuhmfmgs 0.?0.? =.22.5 4.:>.2 0.006
Nkbroghns trfhscnromgs 0.40.4 6.40.3 6.=0.4 0.006
Jfaomfm Nkbroghnstrfhscnromgs 3.=2.: 5.>0.4 4.66.5 0.006
Nkbroghns jghenafmgs 0.02
0.6 6.2
6.4 :.=
2.? 0.006
Bogkfrjfmgrns mn Rnsnrvf Gvrojf y Rnspunstf Gvrojf
Jgrocgaotrgpohf facf y bflf rnspunstf
Dgspotfa hovnrsotfrog Vuorh Mnxnus, BfrjnaghfPnrogmg< 2060-2062Pfjonhtns< 43:
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
5/30
Rnsuatfmgs pgr jojag ohojofmg
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
6/30
Kfrjfmgrns mn Bflf Rnspunstf Gvrojf
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
7/30
Erupgs FKD 10.= he/ka RCF 1 5
O (H
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
8/30
RCF< 15
Zo Hg
=5.=%(6=3/:04)
60.:%(>5/>>>)
FKD10.=
(he/ka)
Zo >=.5%(622/22:)3=.6%
(605/635)23.4%
(6>/>3)
Hg 62,5%(46/3=0)25.5%
(:?/6=6)4.=%
(=2/=??)
O OO
OOO OS
Ohjomnhjof mn Bflf Rnspunstf 1= gvgjotgs rnjupnrfmgs
Jghjgrmfhjof g hg mn ags Bogkfrjfmgrns mn Rnsnrvf Gvrojf
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
9/30
Rnsuatfmgs pgr jojag ohojofmg
O vs OO9 OO vs OOO< HZO vs OOO< p10.06O, OO y OOO vs OS< p10.006
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
10/30
Jfkbogs nh afs Ehs
mgsos^sg mn CZD-r / DKE-u
Feghostfs-EhRD
Afreg
Afreg stgp feghostfs
Cafrn-up
Kojrgmgsos
Fhtfeghostfs mn af EhRD
Gtrfs fatnrhftovfs
Prntrftfkonhtg jgh fhtojghjnptovgs
Dgrkghf mn jrnjokonhtg
Fhmrgenhozfjoh ohtrfgvrojf
Jojag hfturfa
Kfmurfjoh Oh-votrg mn gvgjotgs
Fjukuafjoh mn Gvgjotgs (Sotrocojfjoh)
Mghfjoh mn Gvgjotgs
Fatnrhftovfs tnrfputojfs nh af bflf rnspunstf gvrojf
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
11/30
P. JGR]G F-EHRD SZ. FH]FEGHOZ]FZ / BFLF RNZP^NZ]F
Mnvnsf K.nt fa Eyhnjga Nhmgjrohga, 2060
0
>
60
6>
20
Cafrn-up Fhtfeghost
Jfhjnaaftogh rftn (%) Prnehfhjy rftn/jyjan (%)
Prnehfhjy rftn/ggjytn rntrovfa (%) Prnehfhjy rftn/trfhcnr (%)
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
12/30
]nstgstnrghf 2:,4%
Ohdobomgrns mn af Frgkftfsf 65.2%
Eghzanz-Jgkfmrfh K. nt fa.RBKGhaohn, 2062
Bgsmgu LInt fa. Duk Rnprgm ^pmftn, 2062
Fhmrgenhozfjoh Gvrojf /]fsf mn Nkbfrfzg
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
13/30
MDNF 20,?%
Hfriwojdnfh F. nt fa.RB&N, 206:
Fhmrgenhozfjoh Gvrojf /]fsf mn Nkbfrfzg
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
14/30
Dgrkghf mn Jrnjokonhtg y Bflf Rnspunstf nh COS
Igaobofhfiosnt fa. Duk. Rnprgm. ^pmftn. 6>
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
15/30
Jfkbogs nh afs Ehs
mgsos^sg mn CZD-r / DKE-u
Feghostfs-EhRD
Afreg
Afreg stgp feghostfs
Cafrn-up
Kojrgmgsos
Fhtfeghostfs mn af EhRD
Gtrfs fatnrhftovfs
Prntrftfkonhtg jgh fhtojghjnptovgs
Dgrkghf mn jrnjokonhtg
Fhmrgenhozfjoh ohtrfgvrojf
Jojag hfturfa
Kfmurfjoh Oh-votrg mn gvgjotgs
Fjukuafjoh mn Gvgjotgs (Sotrocojfjoh)
Mghfjoh mn Gvgjotgs
Fatnrhftovfs tnrfputojfs nh af bflf rnspunstf gvrojf
JGROCGAO]RGPOHF FACF77
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
16/30
Jgrocgaotrgpohf facf / Bflf Rnspunstf
FutgrIyrgu,
2062
Mosng PR
Jrotnrogs mnOhjausoh 1> gvgjotgs
PrgtgjgagFhte. Fhte.
NaghvfPurnegh
Pfjonhtns 6> 6=
Nmfm =0,6:,: =0,6:,5
Jfhjnafjoh 3,3% -
H Gvgjotgs =,?:,5 :,?2,2
H Nkb/] 6,36,2 6,?6,=
Nkbfrfzgs : 6
/Pfjo. (%) 20 5,6
/Puhj. (%) 26,= 5,6
/]rfhc. (%) 2:,= 60
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
17/30
Jgrocgaotrgpohf facf / Bflf Rnspunstf
FutgrIyrgu,
2062
Pgayzgs,
2062
Mosng PR R
Jrotnrogs mnOhjausoh 1> gvgjotgs Bgagehf Jrotnrof (BJ)
PrgtgjgagFhte. Fhte. Fhte. Feg
NaghvfPurnegh
Naghvf DKEdpPfjonhtns 6> 6= =: 3=
Nmfm =0,6:,: =0,6:,5 :5,?=,2 :?,6=,6
Jfhjnafjoh 3,3% - :2,3% 24,6%
H Gvgjotgs =,?:,5 :,?2,2 :,=6,2 :,:2,:
H Nkb/] 6,36,2 6,?6,= 6,50,4 -
Nkbfrfzgs : 6 : =
/Pfjo. (%) 20 5,6 5 3,:
/Puhj. (%) 26,= 5,6 66,6 ?
/]rfhc. (%) 2:,= 60 6: 62
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
18/30
Jgrocgaotrgpohf facf / Bflf Rnspunstf
FutgrIyrgu,
2062
Pgayzgs,
2062
Pgayzgs,
206:
Mosng PR R R
Jrotnrogs mnOhjausoh 1> gvgjotgs Bgagehf Jrotnrof (BJ) BJ
PrgtgjgagFhte. Fhte. Fhte. Feg Fhte.
NaghvfPurnegh
Naghvf DKEdp Naghvf-DKEdpPfjonhtns 6> 6= =: 3= =5
Nmfm =0,6:,: =0,6:,5 :5,?=,2 :?,6=,6 :5,5:,?
Jfhjnafjoh 3,3% - :2,3% 24,6% 24%
H Gvgjotgs =,?:,5 :,?2,2 :,=6,2 :,:2,: : (0->)
H Nkb/] 6,36,2 6,?6,= 6,50,4 - 6,?0,3
Nkbfrfzgs : 6 : = 4
/Pfjo. (%) 20 5,6 5 3,: 65
/Puhj. (%) 26,= 5,6 66,6 ? 23
/]rfhc. (%) 2:,= 60 6: 62 24
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
19/30
DKE fctnr jgrocgaaotrgpoh oh yguhe pggr rnspghmnrs
Pgayzgs nt. fa. Duk Rnprgm. mgo< 60.60?:/dukrnp/mnt0=>, 206:Jgrocgaotrgpohf facf y bflf rnspunstf
m b
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
20/30
Cftnko D.nt fa. Duk Rnprgm. 24< 206:
Rnspunstf Gvrojf y ]fsf mn Nkbfrfzgnh jojags jgh Jgrocgaotrgpohf facf.
Jgrocgaotrgpohf facf y bflf rnspunstf
]fsf mn nkbfrfzg nvgautovg (F) y tfsf fjukuafmf mn nkbfrfzg (B)
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
21/30
]fsf mn nkbfrfzg nvgautovg (F) y tfsf fjukuafmf mn nkbfrfzg (B)pgr jojag ohojofmg n ohtnrvfag mn jghcofhzf mna ?>%
(gvgjotgs rnjupnrfmgs y trftfkonhtg)
Cftnko D.nt fa. Duk Rnprgm. 24< 206:Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
22/30
Naghvf
6 2 : = > 3 5 4 ? 60 66
Purnegh
Grefautrfh
NaghvfNH PFJONH]NZ JGH BFLF RNZNRSF CGAOJ^AFR
Jgrocgaaotrgpoh facf Purnegh dJE
2 : = > 3 5 4 ?6
efhornaox
Dgspotfa ^hovnrsotfrog Vuorh Mnxnus, 206:Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
23/30
NaghvfNH PFJONH]NZ JGH BFLF RNZNRSF CGAOJ^AFR
Jrotnrogs mn Ohjausoh,>%
NaghvfNH PFJONH]NZ JGH BFLF RNZNRSF CGAOJ^AFR
Dgspotfa ^hovnrsotfrog Vuorh Mnxnus, 206:Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
25/30
Jojags mnsjfrtfmgs 4/=3 (65.=%)
Naghvf 6>0Purnegh/dKE-DP (^O) 66:>562
Mfs mn nstokuafjoh 60,?2,3
Nstrfmoga mf DJE (pe/ka) ?4?,:=35,2
H mn cgaoj. 862 kk (DJE) =,26,3Puhjoghns :4
H mn Gvgjotgs :,?2,>
H mn Gvgjotgs KOO :,62,0
2 PH 2,:6,2
]rfhscnrnhjofs :3
H mn nkbroghns trfhscnromgs 6,>0,=
H mn nkbfrfzgs 66
NaghvfNH PFJONH]NZ JGH BFLF RNZNRSF CGAOJ^AFR
Dgspotfa ^hovnrsotfrog Vuorh Mnxnus, 206:Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
26/30
Jojags mnsjfrtfmgs 4/=3 (65.=%)
Naghvf 6>0Purnegh/dKE-DP (^O) 66:>562
Mfs mn nstokuafjoh 60,?2,3
Nstrfmoga mf DJE (pe/ka) ?4?,:=35,2
H mn cgaoj. 862 kk (DJE) =,26,3Puhjoghns :4
H mn Gvgjotgs :,?2,>
H mn Gvgjotgs KOO :,62,0
2 PH 2,:6,2]rfhscnrnhjofs :3
H mn nkbroghns trfhscnromgs 6,>0,=
H mn nkbfrfzgs ?
NaghvfNH PFJONH]NZ JGH BFLF RNZNRSF CGAOJ^AFR
Dgspotfa ^hovnrsotfrog Vuorh Mnxnus, 206:Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
27/30
NaghvfNH PFJONH]NZ JGH BFLF RNZNRSF CGAOJ^AFR
Rnsuatfmgs
Dgspotfa ^hovnrsotfrog Vuorh Mnxnus, 206:Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
28/30
CZDr DKE-dp
Jojags 2? 65
Jojags mnsjfrtfmgs >/2? (65.2%) :/65 (65.3%)Naghvf 6>0 6>0
Eghfmgtrgpohfs fmojoghfans (^O) ?>03?? 62:0506
Mfs mn nstokuafjoh 60,?2,3 60,52,=
Nstrfmoga mf DJE (pe/ka) 5??=30 6600=35
H mn cgaoj. 862 kk (DJE) =,=0,? :,?2.6Puhjoghns 2= 6=
H mn Gvgjotgs =,62,6 :,?6,?
H mn Gvgjotgs KOO :,56,? :,>2,6
2 PH 2,46,2 2,26,?
]rfhscnrnhjofs 2: 6:
H mn nkbroghns trfhscnromgs 6,30,: 6,=0,3
H mn nkbfrfzgs 3 :
]fsf mn nkbfrfzg/jojag 20,3% 65,3%
NaghvfNH PFJONH]NZ JGH BFLF RNZNRSF CGAOJ^AFR
Dgspotfa ^hovnrsotfrog Vuorh Mnxnus, 206:Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
29/30
Na usg mn Naghvf (Jgrocgaotrgpohf-facf)ns oeufa mn ncnjtovg qun af fmkohostrfjohmofrof mn CZD pfrf COS.
]nhonhmg nh junhtf qun sokpaocojf natrftfkonhtg, rnmujjoh mn af jfref mnkuatopans ohynjjoghns mofrofs, y rnsuatfmgs
jghsneuomgs, punmn snr uhf gpjoh fjghtnkpafr nh afs pfjonhtns jgh bflfrnspunstf sgkntomfs f COS.
Jghjausoghns/Rncanxoghns
Jgrocgaotrgpohf facf y bflf rnspunstf
7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn
30/30
Dgspotfa ^hovnrsotfrog Vuorh Mnxnus
Erfjofs
pgrvunstrfftnhjoh!